Results 51 to 60 of about 2,631,756 (296)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Are idiopathic and chagasic achalasia two different diseases?

, 2004
Although Chagas' disease esophagopaty and idiopathic (primary) achalasia share several similarities, however, some differences between the two diseases have been noticed. To evaluate if treatment options and their results can be accepted universally, the
Del Grande, J. C., Herbella, FAM, Oliveira, DRCF   +2 more
core   +1 more source

Utilizing fourth-generation endocytoscopy and the ‘enlarged nuclear sign’ for in vivo diagnosis of early gastric cancer

Endoscopy International Open, 2019
Background and study aims Fourth-generation endocytoscopy is an ultra-high magnification endoscopic technique designed to provide excellent quality in vivo histologic assessment of gastrointestinal lesions.
Mary Raina Angeli Abad, Haruhiro Inoue, Haruo Ikeda, Anastassios Manolakis, Enrique Rodriguez de Santiago, Ashish Sharma, Yusuke Fujiyoshi, Hisashi Fukuda, Kazuya Sumi, Manabu Onimaru, Yuto Shimamura   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Urgent revascularization of a liver allograft with a saphenous vein interposition graft between the hepatic artery and the recipient splenic artery after late hepatic artery

, 2005
Digestive Diseases and Sciences, Vol. 50, No. 6 (June 2005), pp. 1177–1180 ( C 2005)Hepatic artery thrombosis (HAT) after liver transplantation is a severe complication which may lead to graft infarction and subsequent graft loss. It complicates 2–12%
Işık, Burak, Söğütlü, Gökhan, Yılmaz, Sezai, Kırımlıoğlu, Vedat, Ara, Cengiz, Battaloğlu, Bektaş, Yılmaz, Mehmet, Kırımlıoğlu, Hale   +7 more
core   +1 more source

Neoadjuvant PD-1 inhibitors plus chemotherapy versus neoadjuvant chemotherapy alone in patients with resectable locally advanced gastric cancer

European Journal of Medical Research
Background Neoadjuvant chemotherapy improves downstaging and survival in locally advanced gastric or esophagogastric junction adenocarcinoma (LAGC/EGJC), but the incremental benefit of adding programmed death-1 (PD-1) blockade and pragmatic perioperative
Zhenshun Li, Aqiang Fan, Mian Wang, Wei Zhou, Jinqiang Liu, Yan Miao, Wanli Yang, Lili Duan, Liaoran Niu, Shushang Liu, Chenyang Wang, Xi Chen, Hanbing Wang, Yu Han, Liu Hong   +14 more
doaj   +1 more source

Reassessing the Baveno based strategy in China: a cost-effectiveness analysis of screening for high-risk varices in cirrhosis

Frontiers in Public Health
Background & AimsThe Baveno consensus recommends using liver stiffness measurement (LSM) and platelet count to avoid endoscopy in low-risk patients with compensated advanced chronic liver disease (cACLD).
Shuhao Su, Jie Luo, Chongxiao Li, Caiyun Yang, Jiaqi Yang, Dawei Ding, Xingchen Liu, Guanya Guo, Ying Han   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases

Virology Journal, 2023
Gastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of gastrointestinal muscle contraction.
Yaqian Li, Qiuyu Chen, Liwei Wang, Xin Chen, Bangmao Wang, Weilong Zhong   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source