Results 71 to 80 of about 2,631,756 (296)

Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot study*

Endoscopy International Open, 2020
Background The incidence of proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) has been increasing. While surgical intervention with Laparoscopic Nissen Fundoplication remains the gold standard, less invasive anti-reflux ...
Haruhiro Inoue, Mayo Tanabe, Enrique Rodríguez de Santiago, Mary Raina Angeli Abad, Yuto Shimamura, Yusuke Fujiyoshi, Akiko Ueno, Kazuya Sumi, Hideomi Tomida, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Orphan Class A GPCRs Signature Predicts Prognosis and Immune Microenvironment in Gastric Cancer: GPR176 Drives Tumor Progression Through Wnt Signaling and Macrophage Polarization

Mediators of Inflammation
Conclusion: These findings may provide new insights into the role of orphan class A GPR genes in STAD and identify GPR176 as a new therapeutic target for GC.
Jiahui Lin, Lingling Ke, Sha Cheng, Wei Lu, Yanan Hu, Xiyi He, Tingting Luo, Yuting Liu, Canxia Xu, Jian Qi   +9 more
doaj   +1 more source

Antioxidant Therapy in Digestive Diseases

Journal of Nutritional Science and Vitaminology, 1993
This paper reviewed the recent advance in the antioxidant therapy for digestive diseases. Many reports have supported that lipid peroxidation mediated by oxygen radicals is implicated in the pathogenesis of gastric mucosal injury, intestinal damage, acute pancreatitis, and liver injury, and several kinds of antioxidant, which are divided into the ...
YOSHIKAWA, Toshikazu, NAITO, Yuji, KONDO, Motoharu   +2 more
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Prevalence of gastroduodenitis and Helicobacter priori infection in a general population sample : relations to symptomatology and life-style

, 2000
Some benign and malignant diseases develop on the background of chronic gastritis or duodenitis. The present study was performed in order to determine the magnitude of these background changes with relations to symptomatology and life style in the ...
Borch, Kurt,, Redéen, Stefan,, Petersson, Fredrik, Jönsson, Kjell-Åke, Franzén, Lennart, Mårdh, Sven,   +5 more
core   +1 more source

Impact of Digestive Diseases on Public Health [PDF]

, 2006
Stanovništvo u Hrvatskoj bilježi trend progresivnog starenja i nalazi se u depopulacijskoj fazi prirodnog kretanja, što za posljedicu ima nepovoljan omjer kategorija osiguranika budući da aktivni osiguranici ne čine ni trećinu osiguranih osoba ...
Banić, Marko, Marko Banić
core   +1 more source