Results 81 to 90 of about 2,631,756 (296)

Comparison of the efficacy of TissuePatch™ versus no TissuePatch™ to seal pancreatic tissue surface for the prevention of pancreatic fistula after radical gastrectomy: study protocol for a prospective, single-center, randomized controlled trial

Trials
Background Pancreatic fistula is a common complication after radical gastrectomy that can be fatal in severe cases. Currently, the avoidance of pressure and thermal injury to the pancreas is the main approach to preventing postoperative pancreatic ...
Chao Yue, Zhenchang Mo, Qinchuan Yang, Pengfei Yu, Haikun Zhou, Ruiqi Gao, Weidong Wang, Zhiyu Guo, Changmin Zhang, Yannian Wang, Panpan Ji, Xiao Wu, Ying Zhang, Gang Ji, Xiaohua Li   +14 more
doaj   +1 more source

The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis

Guoji laonian yixue zazhi
[Objective] To analyze the therapeutic effects, inflammation levels, and safety evaluation of low-dose Fructooligosaccharide combined with Mesalazine in elderly patients with ulcerative colitis.
Wang Fangfang, Ji Xiaoyan, Li Chunhua, Cui Min   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Retrospective Analysis of 411 Cases of Spontaneous Portosystemic Shunt Complicated With Oesophageal and Gastric Variceal Bleeding in Cirrhotic Patients

Canadian Journal of Gastroenterology and Hepatology
This study is aimed at evaluating the incidence and clinical characteristics of spontaneous portosystemic shunts (SPSSs) in cirrhotic patients with oesophageal and gastric variceal bleeding (EGVB) and investigating the impact of SPSSs on the course of ...
Zhaoyi Chen, Jing Li, Xi Wang, Xuecan Mei, Yaxian Kuai, Huixian Li, Derun Kong   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Altered RBC aggregability in diabetes: a threshold for pathophysiological structure-function RBC changes

Cardiovascular Diabetology. Endocrinology Reports
Objective Vascular complications have been associated with pathophysiological RBC changes including reduced RBC deformability (RBCD): the ability of RBCs to change their shape in the microvasculature and increased red blood cell aggregability (RBCA): the
Ifechukwude Ebenuwa, Pierre-Christian Violet, Stephanie Teng, Thom Greene, Nicholas Munyan, Razi Berman, Irene Rozga, Mary Walter, Kenneth J. Wilkins, Nermi Parrow, Mark Levine   +10 more
doaj   +1 more source

Diagnostic and prognostic value of CEA, CA19–9, AFP and CA125 for early gastric cancer

BMC Cancer, 2017
Background The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19–9 (CA19–9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet.
Fan Feng, Yangzi Tian, Guanghui Xu, Zhen Liu, Shushang Liu, Gaozan Zheng, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang   +9 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source