Results 71 to 80 of about 259,386 (311)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Comparison of the digestive enzyme activities in Artemia urmiana from nauplii to adult stages using different diets [PDF]

, 2011
Due to the importance of adult Artemia in aquaculture, information regarding the digestive enzyme activities variation with inexpensive diets has great importance in Artemia at different life stages.
Agh, N., Farhangi, M., Lashkarizadeh, M., Safari, O.   +3 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets [PDF]

, 2017
Background: In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing.
Casteleyn, Christophe, De Smet, Stefaan, Degroote, Jeroen, Fransen, Erik, Michiels, Joris, Prims, Sara, Van Cruchten, Steven, Van Ginneken, Chris, Vergauwen, Hans, Wang, Wei   +9 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Effects of dietary Phaffia rhodozyma on the growth, immunity, antioxidant activity, and digestive tract microbiota of juvenile Strongylocentrotus intermedius

Aquaculture Reports
Strongylocentrotus intermedius is a commercially valuable aquaculture species. Phaffia rhodozyma, a yeast rich in astaxanthin and β-glucans, has immune-enhancing and antioxidant properties in aquatic animals; however, its effects on S. intermedius remain
Yuchun Lu, Teng Teng, Yiwen Lan, Zi-Ao Ren, Yu Du, Feng Liu   +5 more
doaj   +1 more source

Development of Digestive Enzyme of Patin Pangasius hypohthalmus Larvae

Jurnal Akuakultur Indonesia, 2007
Culture of patin Pangasius hypophthalmus especially larval rearing  very depends on the supply of natural food as energy source.  Artemia is the main natural food for fish larvae as a starter food, but its price is high.
I. Effendi, D. Augustine, . Widanarni
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Histological and molecular characterization of the digestive system of early weaned juveniles of Arapaima sp. reared in a recirculating aquaculture system.

PLoS ONE
Arapaima spp., the world's largest scaled freshwater fish, native to the Amazon and Essequibo river basins, are valued in aquaculture for their rapid growth and ornamental appeal.
Maria J Darias, Guillain Estivals, Karl B Andree, Christian Fernández-Méndez, Roger Bazán, Chantal Cahu, Enric Gisbert, Diana Castro-Ruiz   +7 more
doaj   +1 more source

Digestive Enzymatic Activity Profiles and Larval Growth Performance of Barramundi, Lates calcarifer (Bloch, 1790), From Indonesian and Australian Broodstocks

Biotropika: Journal of Tropical Biology
Barramundi fish is one of the most important aquaculture commodities, with cultivation challenges closely related to its survival and growth. There is still a lack of information on digestive enzymatic activity profiles and larval growth, and the use of ...
Gigih Setia Wibawa, Haryanti Haryanti, Nia Kurniawan   +2 more
doaj   +1 more source