Results 41 to 50 of about 29,018 (264)

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Summary of the 2024 report on gastroenterology and digestive endoscopy in China

Chinese Medical Journal
. Background:. China has made significant progress in medical accessibility and quality over the past decades, and quality improvements in gastroenterology and digestive endoscopy have been consistent.
Zheran Chen, Yusi Xu, Lei Xin, Yifei Song, Jinfang Xu, Chu Chu, Chuting Yu, Ye Gao, Xudong Ma, Zhaoshen Li, Luowei Wang, Yuanyuan Ji   +11 more
doaj   +1 more source

Bacteremia caused by digestive system endoscopy.

Revista espanola de enfermedades digestivas, 1999
to evaluate bacteremias caused during endoscopic examination of the digestive tract.prospective study of randomly selected patients who underwent digestive system endoscopic examination. Emergency endoscopic examinations were excluded.a total of 102 patients were analyzed.
J M, Barragán Casas, J M, Hernández Hernández, M A, Garciñuno Jiménez, M A, Gonzalo Molina, P, Carbonero Díaz, R, Ibáñez, R, Serrano-Herranz   +6 more
openaire   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

GastroNet: A robust attention‐based deep learning and cosine similarity feature selection framework for gastrointestinal disease classification from endoscopic images

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Diseases of the Gastrointestinal (GI) tract significantly affect the quality of human life and have a high fatality rate. Accurate diagnosis of GI diseases plays a pivotal role in healthcare systems. However, processing large amounts of medical image data can be challenging for radiologists and other medical professionals, increasing the risk ...
Muhammad Nouman Noor, Muhammad Nazir, Imran Ashraf, Nouf Abdullah Almujally, Muhammad Aslam, Syeda Fizzah Jilani   +5 more
wiley   +1 more source

Direct cholangioscopy for recurrent pancreatitis after choledochal cyst surgery: Its role in diagnosis and surveillance

International Journal of Gastrointestinal Intervention
We report the case of a 20-year-old woman with a complex type “D” pancreaticobiliary maljunction and recurrent pancreatitis who underwent surgical resection with Roux-en-Y reconstruction. Fourteen years later, magnetic resonance cholangiopancreatography (
Mario Brusco, Simona Faraci, Paola De Angelis, Valerio Balassone   +3 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system

Open Medicine, 2016
The authors evaluated the role of endoscopic techniques in the diagnosis and in the potential treatment of neuroendocrine tumors (NET) localized in the gastro-entero-pancreatic system, on the basis of their experience and of the international literature.
Sivero Luigi, Telesca Donato Alessandro, Ruggiero Simona, Russo Teresa, Amato Maurizio, Bianco Tommaso, Amato Bruno, Formisano Cesare, Avellino Manuela, Napolitano Vincenzo   +9 more
doaj   +1 more source

Endoscopic mucosal resection of flat and sessile colorectal adenomas: Our experience with long-term follow-ups [PDF]

Vojnosanitetski Pregled, 2014
Bacground/Aim. Endoscopic mucosal resection (EMR) or mucosectomy is a removing method of flat or sessile lesions, laterally spreading tumors and carcinoma of the colon or the rectum limited to mucosa or the surface part of the submucosa. The aim
Grgov Saša, Dugalić Predrag, Tomašević Ratko, Tasić Tomislav   +3 more
doaj   +1 more source

Diagnostic Accuracy of Size‐Based Preoperative CT Assessment for Predicting Lymph Node Metastasis in Colon Cancer: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
Preoperative CT based on lymph node size shows moderate accuracy for detecting nodal metastasis in colon cancer. In this meta‐analysis of 29 studies (5,634 patients), pooled sensitivity and specificity were 0.69 and 0.66. Size‐based CT alone has limited value for clinical decision‐making.
Yuji Takayama, Tomoya Shimizu, Jun Watanabe, Shimpei Ogawa, Yukihide Kanemitsu   +4 more
wiley   +1 more source