Results 91 to 100 of about 233,064 (313)

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

The Impact and Evolution of COVID-19 on Liver Transplant Recipients Throughout the Pandemic “Waves” in a Single Center

Viruses
Liver transplant recipients (LTRs) have been considered a population group that is vulnerable to COVID-19 as they are chronically immunosuppressed patients with frequent comorbidities.
Clara Fernández Fernández, Blanca Otero Torrón, Mercedes Bernaldo de Quirós Fernández, Rafael San Juan Garrido, Cristina Martín-Arriscado Arroba, Iago Justo Alonso, Alberto Alejandro Marcacuzco Quinto, Óscar Caso Maestro, Félix Cambra Molero, Oana Anisa Nutu, Jorge Calvo Pulido, Alejandro Manrique Municio, Álvaro García-Sesma Pérez-Fuentes, Carmelo Loinaz Segurola   +13 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Expression and localization of Aquaporin 1a in the sea-bass (Dicentrarchus labrax) during ontogeny [PDF]

, 2011
The successful establishment of a species in a given habitat depends on the ability of each of its developing stages to adapt to the environment. In order to understand this process we have studied the adaptation of a euryhaline fish, the sea-bass ...
Guy Charmantier, Charline Abed, Giffard-Mena, Ivone, Guy eCharmantier, Boulo, Viviane, Viviane eBoulo, Ivone Giffard-Mena, Cramb, Gordon, Gordon Cramb, Gordon eCramb, Charmantier, Guy, Charline eAbed, Abed, Charline, Ivone eGiffard-Mena, Viviane Boulo   +14 more
core   +1 more source

Transferable Deep Reinforcement Learning With Edge‐Contour‐Depth Fusion for Autonomous Wireless Capsule Endoscopy Navigation

Advanced Science, EarlyView.
This study presents an anatomical landmark‐guided DRL framework for autonomous wireless capsule endoscopy navigation. Using a lightweight edge‐contour‐depth fusion module, it achieves over 97% coverage across diverse gastric anatomies. To ensure reliability, a two‐stage sim‐to‐real pipeline with an adaptive dynamic programming controller mitigates ...
Haoxuan Wu, Haitao Gao, Qingyang Liu, Sishen Yuan, Haiyang Fang, Mingwu Su, Baijia Liang, Yongzun Yang, Long Bai, Wenzhen Dong, Dihong Xie, Shijian Su, Jiewen Lai, Shing Shin Cheng, Zhen Li, Xiuli Zuo, Hongliang Ren   +16 more
wiley   +1 more source

Outcomes of Pancreas‐Sparing Total Duodenectomy for Severe Duodenal Polyposis in Patients With Familial Adenomatous Polyposis

Annals of Gastroenterological Surgery
Aim Spigelman stage IV duodenal polyposis (SP‐stage IV DP) is associated with high duodenal cancer risk in patients with familial adenomatous polyposis (FAP).
Takehiro Shiraishi, Hideyuki Ishida, Takatoshi Matsuyama, Noriyasu Chika, Yoshiko Mori, Norimichi Chiyonobu, Youichi Kumagai, Ibuki Fujinuma, Toshiro Ogura   +8 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Irritable digestive tract [PDF]

This new nosologic entity known as "Nasio irritable digestive tract", is defined as the reversible, functional neuromyosecreory trouble of the whole or a segment of the digestive tract, that alternates with periods of health with an irregular and
Nasio, Juan
core  

Thoracoscopic esophagectomy with gastric pull-up in megaesophagus secondary to terminal achalasia

Revista Médica del Hospital General de México
In terminal achalasia, the presence of a megaesophagus with loss of axis in its distal third or persistence of symptoms despite multiple previous treatments, the esophagectomy by thoracoscopy with reconstruction by laparoscopic gastric ascent and ...
Rafael Rivera-Avalos, Verónica Rojas-Hernández, César G. Rojas-Benítez, Ernesto Castellanos-Flores, Francisco R. Higuera-Hidalgo, Agustín Etchegaray-Dondé   +5 more
doaj  

Malignancies in Celiac Disease—A Hidden Threat with Diagnostic Pitfalls

Biomedicines
Celiac disease (CeD) is an autoimmune disorder that is triggered by gluten ingestion in genetically predisposed individuals. Untreated or poorly controlled CeD leads to various disease complications, such as malnutrition, osteoporosis, autoimmune ...
Aleksandra Kubas, Ewa Małecka-Wojciesko
doaj   +1 more source