Results 51 to 60 of about 3,012,293 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Information Literacy in the Digital Age: Myths and Principles of Digital Literacy [PDF]

open access: yes, 2018
Librarians have traditionally served as the champions of information literacy, adopting it as a core principle of the profession and creating a movement that tries to facilitate fair, equal access to knowledge and its creation.
Becker, Bernd W.
core   +1 more source

STI in the digital age [PDF]

open access: yesSexually Transmitted Infections, 2007
Immediate access to the newest content, personalised services and an online archive with links to over one and a half million articles As the nature of publishing shifts in a digital age, so the role of a publisher has changed from guardian to gateway, and so our web sites need to facilitate finding content quickly and efficiently.
openaire   +2 more sources

Memory in the digital age

open access: yesOpen Research Europe, 2023
This article explores the configuration of collective memory under the impact of the digital turn. In recent debates, there has been a marked tendency to interpret ‘digital memory’ as a new type of memory, which is radically different from the traditional conceptualization. Even leading authors in the field claim that the digital revolution implies the
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

JOURNALISM IN THE DIGITAL AGE - CHALLENGES AND SOLUTIONS FOR TRAINING WORK

open access: yesTạp chí Khoa học
The vigorous development of the Fourth Industrial Revolution has brought humanity into the digital age. Journalism and journalism training in Vietnam are facing many new problems; advantages and opportunities are intertwined with difficulties and ...
Vu Thi Phuong Le
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Concept of the “Truth Decay” in a Digital Society (an Analytical Review)

open access: yesКонтуры глобальных трансформаций: политика, экономика, право, 2020
The emergence of the “posttruth” phenomenon as the dominance of emotions and opinions over facts, the widespread dissemination of false information, and the rapid growth of fake news in the modern political communication space are the external ...
M. N. Grachev, R. V. Evstifeev
doaj   +1 more source

Creative Destruction and Cultural Lag in the Digital Age [PDF]

open access: yes, 2020
Recently, there has been renewed interest in the two ideas of \u201ccreative destruction\u201d and \u201ccultural lag\u201d both brought together in this article to analyze cutting-edge changes in the digital world, especially as they relate to ...
Degli Esposti, Piergiorgio   +1 more
core   +1 more source

“Open-Minded Couple Seeking a Third”: Queer Women in the Digital Age [PDF]

open access: yes, 2018
The decline of the lesbian bar and the dawn of the digital age, combined with the lack of a sufficient digital hook-up space for queer women, leaves a gaping hole in the potential for lesbian visibility and sociability.
Braaten, Elizabeth
core   +2 more sources

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