Results 61 to 70 of about 3,012,293 (309)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Diagnosing Qur’ānic Precepts on Wealth Creation in Digital Age

Invest Journal of Sharia & Economic Law
This study examines how Islamic economic principles can provide guidance for ethical wealth creation, protection, and distribution in the rapidly evolving digital economy, particularly in the face of cybercrime and financial scams.
Sidiq Uthman Okanlawon, Haruna Zagoon-Sayeed, Taiwo Moshood Salisu   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Work of Art in the Age of Digital Fragility [PDF]

, 2020
Impermanence and fragility have become the defining conditions of the digital age. Technologies that were ubiquitous barely a decade ago, like floppy disks, now look like archaeological relics.
Rubio, Fernando Dominguez, Wharton, Glenn   +1 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Religious Studies Education as a Factor of Societal Religious Security in the Context of Russia's Hybrid War

Cхід
The article is devoted to analyzing the role of religious studies education as one of the key instruments of religious security in countering Russia's religious informational propaganda in its contemporary hybrid wars.
Irina Lomachinska, Svitlana Khrypko, Kristina Binkivska   +2 more
doaj   +1 more source

The Role of Collaboration and Networking in the Digital Age: Students’ Perspectives [PDF]

E-Journal of Humanities, Arts and Social Sciences
In the ever-evolving landscape of the digital age, the dynamics of collaboration and networking have undergone a transformative paradigm shift. This paper delves into the critical role of digital literacy in fostering effective collaboration and ...
Nolizwi Gqwabaza, Thabisa Maqoqa
doaj   +1 more source

Codicological Descriptions in the Digital Age [PDF]

, 2009
Although some of the traditional roles played by codicological descriptions in the print era have not changed when translated to digital environments, other roles have been redefined and new ones have emerged.
Stinson, Timothy
core  

Street cred : are media consumers craving more “authenticity” in the digital age? [PDF]

, 2018
Media organizations that provide news have traditionally relied on audience perceptions of truth and credibility to lure more readers, viewers, and listeners.
Schulz, George Warren
core   +1 more source