Results 51 to 60 of about 37,398,274 (259)

Instructional design of smart technology use in teacher digital educational environment

Образование и наука, 2023
Introduction. According to the provisions mentioned in Digital Kazakhstan Programme and Digital Teacher national project, the teacher today is regarded not just as an active user of the novel digital and smart technologies, but as the creator and ...
G. B. Sarzhanova, R. S. Bobesh, G. Zh. Smagulova, A. Turkel, N. B. Serikbayeva   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Digital transformation of the educational process in schools of Kazakhstan: the concept of intelligent assistant in school physics curriculum

Frontiers in Education
BackgroundThe current stage of Kazakhstan’s development is characterized by the formation of a digital economy. One of its aspects involves improving the quality of education through its digital transformation.
Victoria Grankina, Irina Krasnikova, Yuliya Smirnova, Irina Kulibaba, Vladimir Barinov   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A Human-Centered Digital Assistant In Dentistry

International Dental Journal
Aim or purpose: To develop and evaluate an AI-powered digital solution that addresses clinical oversights and improves both practitioner efficiency and patient understanding in dental care. Materials and methods: A voice-recognition and AI-based platform
Delila Leyvraz, Xavier Leyvraz
doaj   +1 more source

Handheld computers and the 21^st century surgical team: a pilot study

BMC Medical Informatics and Decision Making, 2005
Background The commercial development and expansion of mobile phone networks has led to the creation of devices combining mobile phones and personal digital assistants, which could prove invaluable in a clinical setting. This pilot study aimed to look at
Paraskeva Paraskevas, Netuveli Gopalakrishnan, Panesar Sukhmeet S, Aziz Omer, Sheikh Aziz, Darzi Ara   +5 more
doaj   +1 more source

clij/clijx-assistant-imagej3dsuite: 0.4.1.0

, 2020
See also https://github.com/clij/clij2/releases/tag/2.2.0.11 https://github.com/clij/clijx/releases/tag/0.30.1.0 https://github.com/clij/assistant/releases/tag/0.4.1.
Robert Haase
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The L'ART Research Assistant: A digital toolkit for bilingualism and language attitude research [PDF]

In this paper, we present the L’ART Research Assistant, a freely available open-source app to aid researchers in the collection, storage and transfer of data for research in bilingualism and language attitudes, with a particular focus on bilingual ...
Gruffydd, Ianto, Breit, Florian, Tamburelli, Marco, Brasca, Lissander   +3 more
core   +3 more sources