Results 31 to 40 of about 36,482,451 (268)

RNA Biomarkers as a Response Measure for Survival in Patients with Metastatic Castration-Resistant Prostate Cancer

, 2021
Treatment evaluation in metastatic castration-resistant prostate cancer is challenging. There is an urgent need for biomarkers to discriminate short-term survivors from long-term survivors, shortly after treatment initiation.
Irma M. Oving, Paul Hamberg, Vincent O. Dezentjé, Nielka P. van Erp, Levi Groen, Niven Mehra, Jack A. Schalken, Guillemette E. Benoist, Inge M. van Oort, Gerald W. Verhaegh, Emmy Boerrigter, Onno van Hooij, Pieter de Mol, Tineke J. Smilde, Anton F. J. de Haan, Frank Smit, Diederik M. Somford   +16 more
core   +1 more source

Mitigating the influence of domain shift in skin lesion classification: A benchmark study of unsupervised domain adaptation methods

Informatics in Medicine Unlocked
The potential of deep neural networks in skin lesion classification has already been demonstrated to be on-par if not superior to the dermatologists’ diagnosis in experimental settings.
Sireesha Chamarthi, Katharina Fogelberg, Titus J. Brinker, Julia Niebling   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Superhuman performance on urology board questions using an explainable language model enhanced with European Association of Urology guidelines

ESMO Real World Data and Digital Oncology
Background: Large language models encode clinical knowledge and can answer medical expert questions out-of-the-box without further training. However, this zero-shot performance is limited by outdated training data and lack of explainability impeding ...
M.J. Hetz, N. Carl, S. Haggenmüller, C. Wies, J.N. Kather, M.S. Michel, F. Wessels, T.J. Brinker   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Human-centered AI as a framework guiding the development of image-based diagnostic tools in oncology: a systematic review

ESMO Real World Data and Digital Oncology
Background: Artificial intelligence diagnostic tools (AIDTs) in oncology show high image classification accuracy but limited clinical adoption. Their adoption could be enhanced by (i) using user feedback during the software design, (ii) demonstrating ...
K. Allen, A.K. Yawson, S. Haggenmüller, J.N. Kather, T.J. Brinker   +4 more
doaj   +1 more source

Real-Life Multimarker Monitoring in Patients with Heart Failure: Continuous Remote Monitoring of Mobility and Patient-Reported Outcomes as Digital End Points in Future Heart-Failure Trials

Digital Biomarkers, 2020
Aims: Heart failure (HF) affects approximately 26 million people worldwide. With an aging global population, innovative approaches to HF evaluation and management are needed to cope with the worsening HF epidemic.
Frank Kramer, Javed Butler, Sanjiv J. Shah, Christian Jung, Savina Nodari, Stephan Rosenkranz, Michele Senni, Luke Bamber, Stephan Cichos, Chrysanthi Dori, Toeresin Karakoyun, Gabriele Jenny Köhler, Kinjal Patel, Paolo Piraino, Thomas Viethen, Praneeth Chennuru, Ayse Paydar, Jason Sims, Richard Clark, Rob van Lummel, Alexandra Müller, Chad Gwaltney, Salko Smajlovic, Hans-Dirk Düngen, Wilfried Dinh   +24 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Comparing Patient’s Confidence in Clinical Capabilities in Urology: Large Language Models Versus Urologists

European Urology Open Science
Background and objective: Data on interaction of patients with artificial intelligence (AI) are limited, primarily derived from small-scale studies, cross-sectional surveys, and qualitative reviews.
Nicolas Carl, Lisa Nguyen, Sarah Haggenmüller, Martin Joachim Hetz, Jana Theres Winterstein, Friedrich Otto Hartung, Britta Gruene, Jakob Nikolas Kather, Tim Holland-Letz, Maurice Stephan Michel, Frederik Wessels, Titus Josef Brinker   +11 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source