Results 81 to 90 of about 3,004,176 (304)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Collection Management Strategies in a Digital Environment.

open access: yesIssues in Science and Technology Librarianship, 2001
This paper describes a grant-funded research project to relocate selected print journal runs, for which an electronic version is available, to remote storage from the shelves of campus libraries at the University of California. During the project, users
Cecily Johns
doaj   +1 more source

Guide to the WillaKenzie Estate Papers [PDF]

open access: yes, 2015
WillaKenzie Estate, established by Ronni and Bernard Lacroute, is located in Yamhill, Oregon in the rolling hills of the Yamhill-Carlton AVA. The first vines were planted in 1992 and additional plantings continued through 2001.
Linfield College Archives
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

VR Applications for Cultural Heritage: Harnessing Proxemics and Interactivity for Heritage Dissemination

open access: yesimg journal
Recently, Virtual Reality (VR) has witnessed remarkable growth across various fields, such as education, gaming, and entertainment. In the cultural heritage domain, VR has demonstrated its significance by enabling digital reconstructions of buildings and
Fabrizio Banfi   +3 more
doaj   +1 more source

Holding it together: an exploratory study on the social structures of digital collection management [PDF]

open access: yesDigital Transformation and Society
Purpose – The academic library’s physical capacity and its service obligations to local users structured the traditional print collection. Largely freed of these constraints, the digital collection manager enjoys unprecedented freedoms but now contends ...
Paul Rosenstein
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Digital Collection Management through the Library Catalog

open access: yesInformation Technology and Libraries, 2006
Digitization has bestowed upon librarians and archivists of the late 20th and early 21st centuries the opportunity to reexamine how they access their collections.
Michaela Brenner   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

The First World War Letters of H.J.C. Peirs: A Digital History

open access: yes, 2019
This poster provides a high-level overview of The First World War Letters of H.J.C. Peirs: A Digital History project, giving information on its creation, the collection of letters, how it has used digital mapping, and its use in the ...
Isherwood, Ian A.   +2 more
core  

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