Results 81 to 90 of about 1,846,658 (288)
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Location, safety and (non) strangers in gay men’s narratives on ‘hook-up’ apps [PDF]
, 2016 Hook-up websites and apps are said to be transforming the sexual lives of gay men and have been linked with the apparent erosion of gay publics as the basis for identity politics and social action.
Davis, Mark +4 more
core +3 more sources
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
DevOps is Bigger than IT: Driving Digital Transformation in Libraries [PDF]
, 2020 The DevOps movement represents a paradigm shift in software development, but there are misconceptions about what it really means. It’s much more nuanced than simply adding a DevOps engineer to your team or asking systems administrators and developers to ...
Snapp, Mary Beth, Vinopal, Jennifer
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
PROPERTY RELATIONS IN CINEMATOGRAPHY: EVALUATION, EVOLUTION, MANAGEMENT
Вестник университета, 2020 The process of gradual reform of property relations in cinematography in order to transition to a competitive market has been considered. The possible consequences of a reduction in the public sector in this area of activity have been analysed in detail.
M. I. Pankratova
doaj +1 more source
Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou +12 more
wiley +1 more source
Arts, Culture and Californians Charting Arts Participation and Organizations in a Vast, Diverse State [PDF]
, 2011 Arts and culture play a significant role in the daily lives of Californians. The state is noteworthy for the avid participation of its people, the diversity and abundance of its arts organizations and the varied regional characteristics of its arts ...
Ann Markusen +3 more
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