Results 61 to 70 of about 739,270 (302)

Social intelligence and pathological gaming: a longitudinal study of the associations among negative emotions, social intelligence, aggression, and pathological gaming in adolescents

Frontiers in Psychiatry
IntroductionPathological gaming continues to be highlighted as one of the most critical issues concerning adolescents. Numerous studies have aimed to elucidate the relationships between adolescents' negative emotions (e.g., peer stress, anxiety ...
Sung Je Lee, Eui Jun Jeong, Jae In Choi, Man Su Park   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Platformisation of Consumer Culture : A Digital Methods Guide [PDF]

This book offers a unique methodological guide for social and marketing scholars interested in understanding and using digital methods to explore the processes of platformisation of consumer culture unfolding on digital media.
A. Caliandro, L. Bainotti, Alessandro Caliandro, Anselmi, Guido, Caliandro, Alessandro, A. Gandini, Gandini, Alessandro, Alessandro Gandini, Lucia Bainotti, Guido Anselmi, G. Anselmi, Bainotti, Lucia   +11 more
core   +1 more source

The influence of negative emotions on adolescents' pathological gaming: the role of self-control in the associations with aggression, academic stress, and pathological gaming

Frontiers in Psychology
IntroductionLong-term exposure to negative emotions (e. g., anxiety, depression, loneliness) in adolescents has been reported to inhibit psychological growth and contribute to academic stress, aggression, and problem behaviors, including pathological ...
Jeong Ae Kim, Jae In Choi, Sung Je Lee, Eui Jun Jeong   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Parenting attitudes and pathological gaming: multifaceted influences of harsh-negative parenting on adolescent pathological gaming

Frontiers in Psychology
IntroductionAs adolescent pathological gaming is increasingly recognized as a societal issue, previous research has aimed to identify the effects of family-related factors (e.g., parenting attitudes, parent–child relationship, etc.) and adolescents ...
Jae In Choi, Gyoung Mo Kim, Jeong Ae Kim, Eui Jun Jeong   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Beyond Surveillance: How Do Markets and Algorithms "Think"?

Genealogy+Critique, 2017
This paper draws on Foucault's work to inspire and inform a conceptual investigation into the relationship between economic thinking, in particular concerning markets, and contemporary computing.
Bernhard Rieder
doaj   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Young people and Facebook: What are the challenges to adopting a critical engagement? [PDF]

, 2013
This article presents findings from a recent study into the ways young people are engaging with the social networking site Facebook. It draws on a qualitative, small-scale study with six 13 and 14 year old girls who have been using Facebook daily for two
Luciana Pangrazio
core