Results 51 to 60 of about 39,110,992 (291)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Frontiers in PsychologyIntroductionIt is important to explore how words are given to body awareness in Mindfulness-Based Stress Reduction (MBSR), as this impacts health and illness, while the literature on this topic is scarce.
Ingeborg van den Bold +2 more
doaj +1 more source
Emotions in digital context: Finnish way of saying Pick me; we could make a good couple!
Revista Teknokultura, 2012 The world has become thoroughly mediated. Dating ads are cultural representations for negotiations of shared cultural models and evident personal meanings given to hetero-relationship.
Anne Holappa
doaj +1 more source
A Long-Tailed Image Classification Method Based on Enhanced Contrastive Visual Language
Sensors, 2023 To solve the problem that the common long-tailed classification method does not use the semantic features of the original label text of the image, and the difference between the classification accuracy of most classes and minority classes are large, the ...
Ying Song, Mengxing Li, Bo Wang
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Frontiers in PsychiatryIntroductionPathological gaming continues to be highlighted as one of the most critical issues concerning adolescents. Numerous studies have aimed to elucidate the relationships between adolescents' negative emotions (e.g., peer stress, anxiety ...
Sung Je Lee +3 more
doaj +1 more source
Enduring Victoria: Iconoclasm and Restoration at the British Embassy in Tehran
19, 2022 This article will address curatorial challenges faced by the Government Art Collection in the repatriation, conservation, and selection of a new display for the British ambassador’s residence in Tehran following an attack by Iranian protesters in 2011 ...
Andrew Parratt, Laura Maria Popoviciu
doaj +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Frontiers in PsychologyIntroductionLong-term exposure to negative emotions (e. g., anxiety, depression, loneliness) in adolescents has been reported to inhibit psychological growth and contribute to academic stress, aggression, and problem behaviors, including pathological ...
Jeong Ae Kim +3 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source