Results 51 to 60 of about 739,270 (302)

Queer Digital Cultures

open access: yes, 2020
This chapter examines queer digital culture, a term that refers to the ways in which LGBTQ+ identities, practices, and theories have been mixed up in the emergence, design, and constitution of digital technology. It highlights significant shifts at the intersections of queer identity and politics and digital communication technologies from the 1980s to
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A Long-Tailed Image Classification Method Based on Enhanced Contrastive Visual Language

open access: yesSensors, 2023
To solve the problem that the common long-tailed classification method does not use the semantic features of the original label text of the image, and the difference between the classification accuracy of most classes and minority classes are large, the ...
Ying Song, Mengxing Li, Bo Wang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Language-games in live mindfulness-based stress reduction: a philosophy of language analysis of participant-trainer dialogue

open access: yesFrontiers in Psychology
IntroductionIt is important to explore how words are given to body awareness in Mindfulness-Based Stress Reduction (MBSR), as this impacts health and illness, while the literature on this topic is scarce.
Ingeborg van den Bold   +2 more
doaj   +1 more source

Emotions in digital context: Finnish way of saying Pick me; we could make a good couple!

open access: yesRevista Teknokultura, 2012
The world has become thoroughly mediated. Dating ads are cultural representations for negotiations of shared cultural models and evident personal meanings given to hetero-relationship.
Anne Holappa
doaj   +1 more source

Enduring Victoria: Iconoclasm and Restoration at the British Embassy in Tehran

open access: yes19, 2022
This article will address curatorial challenges faced by the Government Art Collection in the repatriation, conservation, and selection of a new display for the British ambassador’s residence in Tehran following an attack by Iranian protesters in 2011 ...
Andrew Parratt, Laura Maria Popoviciu
doaj   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

ALGORITHMIC LITERACIES: IDENTIFYING EDUCATIONAL MODELS AND HEURISTICS FOR ENGAGING THE CHALLENGE OF ALGORITHMIC CULTURE [PDF]

open access: yes, 2023
Algorithms are interwoven in the fabric of digital culture. They increasingly mediate our experience of politics, culture, identity, and agency. Building on critical research in other fields, critical educational theorists are exploring the pervasive ...
Jason Nolan   +5 more
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