Results 41 to 50 of about 36,775,918 (294)

Digital Earth – A sustainable Earth

IOP Conference Series: Earth and Environmental Science, 2014
All life, particularly human, cannot be sustainable, unless complimented with shelter, poverty reduction, provision of basic infrastructure and services, equal opportunities and social justice. Yet, in the context of cities, it is believed that they can accommodate more and more people, endlessly, regardless to their carrying capacity and increasing ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Crop Phenology Detection Using High Spatio-Temporal Resolution Data Fused from SPOT5 and MODIS Products

Sensors, 2016
Timely and efficient monitoring of crop phenology at a high spatial resolution are crucial for the precise and effective management of agriculture. Recently, satellite-derived vegetation indices (VIs), such as the Normalized Difference Vegetation Index ...
Yang Zheng, Bingfang Wu, Miao Zhang, Hongwei Zeng   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Wavelet-Based Rust Spectral Feature Set (WRSFs): A Novel Spectral Feature Set Based on Continuous Wavelet Transformation for Tracking Progressive Host–Pathogen Interaction of Yellow Rust on Wheat

Remote Sensing, 2018
Understanding the progression of host–pathogen interaction through time by hyperspectral features is vital for tracking yellow rust (Puccinia striiformis) development, one of the major diseases of wheat.
Yue Shi, Wenjiang Huang, Pablo González-Moreno, Belinda Luke, Yingying Dong, Qiong Zheng, Huiqin Ma, Linyi Liu   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fusion of Airborne Discrete-Return LiDAR and Hyperspectral Data for Land Cover Classification

Remote Sensing, 2015
Accurate land cover classification information is a critical variable for many applications. This study presents a method to classify land cover using the fusion data of airborne discrete return LiDAR (Light Detection and Ranging) and CASI (Compact ...
Shezhou Luo, Cheng Wang, Xiaohuan Xi, Hongcheng Zeng, Dong Li, Shaobo Xia, Pinghua Wang   +6 more
doaj   +1 more source

ScienceEarth: A Big Data Platform for Remote Sensing Data Processing

Remote Sensing, 2020
Mass remote sensing data management and processing is currently one of the most important topics. In this study, we introduce ScienceEarth, a cluster-based data processing framework.
Chen Xu, Xiaoping Du, Zhenzhen Yan, Xiangtao Fan   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Time-Series InSAR Monitoring of Permafrost Freeze-Thaw Seasonal Displacement over Qinghai–Tibetan Plateau Using Sentinel-1 Data

Remote Sensing, 2019
Permafrost is widely distributed in the Tibetan Plateau. Seasonal freeze−thaw cycles of permafrost result in upward and downward surface displacement.
Xuefei Zhang, Hong Zhang, Chao Wang, Yixian Tang, Bo Zhang, Fan Wu, Jing Wang, Zhengjia Zhang   +7 more
doaj   +1 more source