Results 61 to 70 of about 885,548 (303)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Digital Earth in Europe [PDF]

, 2019
Abstract In recent years, with the advancements in technology and research as well as changes in society, Digital Earth transformed. It evolved from its original concept of a 3D multilayer representation of our planet into a more practical system design to fulfil the demand for information sharing, which now embraces fields such as global climate ...
Marconcini, Mattia, Esch, Thomas, Bachofer, Felix, Metz-Marconcini, Annekatrin   +3 more
openaire   +2 more sources

Capabilities of Chinese Gaofen-3 Synthetic Aperture Radar in Selected Topics for Coastal and Ocean Observations

Remote Sensing, 2018
Gaofen-3 (GF-3), the first Chinese spaceborne synthetic aperture radar (SAR) in C-band for civil applications, was launched on August 2016. Some studies have examined the use of GF-3 SAR data for ocean and coastal observations, but these studies ...
Xiao-Ming Li, Tianyu Zhang, Bingqing Huang, Tong Jia   +3 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Digital Earth: Big Earth Data

International Journal of Digital Earth, 2014
Human beings have entered the age of ‘big data’. From 2005 to 2020, the digital universe is expected to grow by a factor of 300, from 130 exabytes to 40,000 exabytes, or 40 trillion gigabytes.
openaire   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A Cluster of CO2 Change Characteristics with GOSAT Observations for Viewing the Spatial Pattern of CO2 Emission and Absorption

Atmosphere, 2015
Satellite observations can be used to detect the changes of CO2 concentration at global and regional scales. With the column-averaged CO2 dry-air mole fraction (Xco2) data derived from satellite observations, the issue is how to extract and assess these ...
Da Liu, Liping Lei, Lijie Guo, Zhao-Cheng Zeng   +3 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Geostatistical Analysis of CH4 Columns over Monsoon Asia Using Five Years of GOSAT Observations

Remote Sensing, 2016
The aim of this study is to evaluate the Greenhouse gases Observation SATellite (GOSAT) column-averaged CH4 dry air mole fraction (XCH4) data by using geostatistical analysis and conducting comparisons with model simulations and surface emissions ...
Min Liu, Liping Lei, Da Liu, Zhao-Cheng Zeng   +3 more
doaj   +1 more source

From digital Earth to smart Earth

Chinese Science Bulletin, 2014
This article will analyze the achievements of the digital Earth concept and further introduce two key technologies, the internet of things and cloud computing. Both these technologies are accelerating the development of digital Earth toward a new concept—smart Earth.
Deren Li, Yuan Yao, Zhenfeng Shao, Le Wang   +3 more
openaire   +1 more source