Results 81 to 90 of about 5,255,523 (302)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer

Scientific Reports
Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis of TOP2A from a pan-cancer perspective, despite its significance.
Jin Zhang, Tianxiao Yang, Kenie Wang, Jie Pan, Junjun Qiu, Shengnai Zheng, Xuesong Li, Guanghao Li   +7 more
doaj   +1 more source

Early form of mitochondrial epileptic encephalopathy due to primary deficiency of coenzyme Q10

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Epileptic encephalopathy (EE) is a group of genetic monogenic diseases with leading feature of intractable epilepsy with onset at an early age and the development of neurocognitive deficit.
T. V. Melashenko, S. A. Laptiev, D. I. Malekov, M. Yu. Fomina, O. G. Novoselova, R. A. Bikanov, D. S. Tsibulskaya, A. V. Smirnova   +7 more
doaj   +1 more source

Exploitation of Digital Filters to Advance the Single-Phase T/4 Delay PLL System [PDF]

, 2016
With the development of digital signal processing technologies, control and monitoring of power electronics conversion systems have been evolving to become fully digital.
Blaabjerg, Frede, Yang, Yongheng, Zhou, Keliang   +2 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A Patient-Centered Framework for Evaluating Digital Maturity of Health Services: A Systematic Review [PDF]

, 2015
© Kelsey Flott, Ryan Callahan, Ara Darzi, Erik Mayer.Background: Digital maturity is the extent to which digital technologies are used as enablers to deliver a high-quality health service. Extensive literature exists about how to assess the components of
Callahan, R, Darzi, A, Flott, K, Mayer, E   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science
Immune checkpoint blockade (ICB) efficacy is limited by tumor‐intrinsic immune escape mechanisms. This study identifies the transcription factor ZBTB21 as a central orchestrator of dual immunosuppressive programs. ZBTB21 epigenetically silences gasdermin
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
doaj   +1 more source

Machine Learning Model Discriminate Ischemic Heart Disease Using Breathome Analysis

Biomedicines
Background: Ischemic heart disease (IHD) impacts the quality of life and is the most frequently reported cause of morbidity and mortality globally. Aims: To assess the changes in the exhaled volatile organic compounds (VOCs) in patients with vs.
Basheer Abdullah Marzoog, Peter Chomakhidze, Daria Gognieva, Nina Vladimirovna Gagarina, Artemiy Silantyev, Alexander Suvorov, Ekaterina Fominykha, Malika Mustafina, Ershova Natalya, Aida Gadzhiakhmedova, Philipp Kopylov   +10 more
doaj   +1 more source

Synthetic aperture radar target simulator [PDF]

, 1984
A simulator for simulating the radar return, or echo, from a target seen by a SAR antenna mounted on a platform moving with respect to the target is described.
Bickler, T. C., Goldstein, R. M., Held, D. N., Zebker, H. A.   +3 more
core   +1 more source