Results 61 to 70 of about 5,255,523 (302)

A Fully Differential Digital CMOS Pulse UWB Generator [PDF]

open access: yes, 2009
A new fully-digital CMOS pulse generator for impulse-radio Ultra-Wide-Band (UWB) systems is presented. First, the shape of the pulse which best fits the FCC regulation in the 3.1-5 GHz sub-band of the entire 3.1-10.6 GHz UWB bandwidth is derived and ...
C. Buccella   +16 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Data-Driven Reporting and Processing of Digital Archives with Brunnhilde [PDF]

open access: yes, 2017
[Excerpt] Archivists are now several decades in to appraising, arranging, describing, preserving, and providing access to digital archives and have developed and adopted a number of tools to aid in specific tasks along the way.
Walsh, Tim
core   +1 more source

Talking With Scholars: Developing a Research Environment for Oral History Collections [PDF]

open access: yes, 2014
Scholars are yet to make optimal use of Oral History collections. For the uptake of digital research tools in the daily working practice of researchers, practices and conventions commonly adhered to in the subfields in the humanities should be taken into
de Jong, Franciska   +3 more
core   +5 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Repair of articular cartilage defects with intra-articular injection of autologous rabbit synovial fluid-derived mesenchymal stem cells

open access: yesJournal of Translational Medicine, 2018
Background The role of rabbit synovial fluid-derived mesenchymal stem cells (rbSF-MSCs) in cartilage defect repair remains undefined. This work evaluates the in vivo effects of rbSF-MSCs to repair knee articular cartilage defects in a rabbit model ...
Zhaofeng Jia   +8 more
doaj   +1 more source

Research Notes on the Emerging Concepts of Digital Heritage in Brazil [PDF]

open access: yes, 2010
This paper presents the first results in our investigation of the emerging Digital Heritage concepts in Brazil. It focuses on the analysis of a government experience with social media intended to prepare an official report on digital culture.
Dantas, Camila Guimaraes, Dodebei, Vera
core  

Recreating first digit with silicone prosthesis

open access: yesNational Journal of Maxillofacial Surgery, 2019
The hand is an integral part of our body. Any deviation in hand anatomy not only affects the day-to-day function but it even results in unesthetic appearance. Rehabilitation of these deformities is done either by microsurgery or with the help of silicone prosthesis. Nonsurgical treatment was carried out, where rehabilitation of the first digit was done
Gaikwad, Amit Mahadeo   +3 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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