Results 151 to 160 of about 695,889 (286)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Developing a digital game for excel skills learning in higher education - a comparative study analyzing differences in learning between digital games and textbook learning. [PDF]

Educ Inf Technol (Dordr), 2023
Chen MY, Tang JT.
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Comparison of digital games as a cognitive function assessment tool for current standardized neuropsychological tests. [PDF]

Braz J Anesthesiol, 2022
Goulart AA, Lucatelli A, Silveira PSP, Siqueira JO, Pereira VFA, Carmona MJC, Valentin LSS, Vieira JE.   +7 more
europepmc   +1 more source

Digital Game Piracy

, 2011
The practice of illegally copying and distributing digital games is at the heart of one of the most heated and divisive debates in the international games environment. Despite the substantial interest in game piracy, there is very little objective information available about its magnitude or its distribution across game titles and game genres.
Drachen, Anders, Veitch, Rob, Bauer, Kevin   +2 more
openaire   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Skin‐Inspired Design of Self‐Healing Coatings Integrating Interface‐Liquid Repellency and Corrosion Resistance

Advanced Science, EarlyView.
A skin‐inspired multilayered coating system is developed to integrate multiple, often conflicting, functions of self‐healing capability, strong liquid repellency, long‐term corrosion resistance, and robust adhesion, to tackle diverse challenges in engineering services.
Bingzhi Li, Bingce Liu, Enyu Guo, Zhihao Zhou, Yibo Ouyang, Xiao‐Bo Chen, Huijun Kang, Zongning Chen, Tongmin Wang   +8 more
wiley   +1 more source

Innovating Occupational Safety Training: A Scoping Review on Digital Games and Possible Applications in Agriculture. [PDF]

Int J Environ Res Public Health, 2021
Vigoroso L, Caffaro F, Micheletti Cremasco M, Cavallo E.   +3 more
europepmc   +1 more source

Digital literacy games

Frontiers in Communication
This paper presents the results of a systematic literature review of academic publications about digital literacy games. We have analyzed a total of 30 papers and book chapters published in English, Spanish, Portuguese and Dutch between 2005 and 2021 and stored in Scopus.
De La Hera, Teresa, Sanz, Laura Cañete, Sierra, Nuria Navarro, Jansz, Jeroen, Kneer, Julia, Glas, René, van Vught, Jasper   +6 more
openaire   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source