Results 31 to 40 of about 571,701 (277)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Generative artificial intelligence in healthcare from the perspective of digital media: Applications, opportunities and challenges

Heliyon
Introduction: The emergence and application of generative artificial intelligence/large language models (hereafter GenAI LLMs) have the potential for significant impact on the healthcare industry. However, there is currently a lack of systematic research
Rui Xu, Zhong Wang
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

What role does corporate governance play in the intention to use cloud computing technology? [PDF]

, 2019
This paper aims to investigate the factors which promote the adoption of cloud-based technology. It strives for a better understanding of the impact of corporate governance on the adoption of this technology.
Palos Sánchez, Pedro Ramiro, Robina Ramírez, Rafael, Velicia Martín, Félix Antonio   +2 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Brazil’s over-centralised governance of digital transformation

The African Journal of Information and Communication, 2022
This article analyses governance of Brazil’s Digital Transformation Strategy (E-Digital) through a new public governance (NPG) lens. Based on the analysis, the author finds that governance of E-Digital is too centralised, with too much decision-making ...
Larissa Galdino de Magalhães Santos
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Enhanced multi-task deep reinforcement learning for the integrated inventory-routing problem under VMI mode

Management System Engineering
Effective inventory replenishment and routing are crucial for minimizing supply chain costs and enhancing operational efficiency. In this paper, we focus on the integrated optimization of inventory replenishment and routing problems in Vendor Managed ...
Gang Lu, Junmin Wan, Lijing Du, Xiaofang Chen   +3 more
doaj   +1 more source

Can the digitalization level of agriculture improve its ecological efficiency under carbon constraints: Evidence from China

Heliyon
The interplay between digitalization and economic development constitutes a pivotal global issue, yet empirical research on agricultural ecological efficiency in developing countries remains limited.
Haoran Wang, Zhuangzhuang Li
doaj   +1 more source

Large Scale Document Management System: Creating Effective Public Sector Knowledge Management System [PDF]

, 2010
The digital age has redefined the production process and utilisation of documents globally. In the information age, the process of input, delivery, storage, receipt, and categorization of data is critical.
Bolu, Christian
core   +1 more source