Results 41 to 50 of about 36,181,116 (300)

Evolutionary logic and operational mechanism of digital governance in rural tourism: A case study of Jiebang Village in Shanghai and Wusi Village in Zhejiang [PDF]

Ziyuan Kexue
[Objective] In the process of rural revitalization and digital village construction, digital technologies are profoundly reshaping rural tourism governance, serving as a key driver in promoting the transformation of grassroots social governance and the ...
LIU Yixue, ZHOU Xiaohui, ZHANG Jinhe
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adaptive spatial-channel feature fusion and self-calibrated convolution for early maize seedlings counting in UAV images

Frontiers in Plant Science
Accurate counting of crop plants is essential for agricultural science, particularly for yield forecasting, field management, and experimental studies. Traditional methods are labor-intensive and prone to errors.
Zhenyuan Sun, Zhenyuan Sun, Zhenyuan Sun, Zhi Yang, Zhi Yang, Yimin Ding, Yimin Ding, Boyan Sun, Boyan Sun, Saiju Li, Saiju Li, Zhen Guo, Zhen Guo, Lei Zhu, Lei Zhu   +14 more
doaj   +1 more source

Complexity, Governance and Networks: Introduction to the Inaugural Issue

, 2014
From the introduction: 1. Yet Another Journal? Why is it necessary to publish a new journal about complexity, governance, and networks? There has been an increasing interest in complexity, governance, and network studies in recent decades.
Morçöl, Göktuğ, Gerrits, Lasse, Teisman, Geert   +2 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tabling sustainable commodities through private governance [PDF]

, 2013
Over the past few decades, new types of private governance arrangements arose which increasingly shape outcomes in global governance. The object of this dissertation is a specific form of private governance arrangement which emerged in the early 2000s in
Environmental Governance, Schouten, A.M., Section Environmental Governance   +2 more
core  

Adaptive Governance and sub-national Climate Change Policy: A comparative analysis of Khyber Pukhtunkhawa and Punjab Provinces in Pakistan

, 2019
This study explores the adaptive governance and effective implementation of climate policies at the subnational level in a developing country context. We focused on Pakistan as our central case as it is considered one of the most vulnerable countries to ...
H. Ali, Saleem, Mumtaz, Muhammad
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enhanced multi-task deep reinforcement learning for the integrated inventory-routing problem under VMI mode

Management System Engineering
Effective inventory replenishment and routing are crucial for minimizing supply chain costs and enhancing operational efficiency. In this paper, we focus on the integrated optimization of inventory replenishment and routing problems in Vendor Managed ...
Gang Lu, Junmin Wan, Lijing Du, Xiaofang Chen   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source