Results 31 to 40 of about 52,744 (259)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Frontiers in Public HealthBackgroundChina is actively promoting cancer drugs insurance (CDI) to alleviate the growing burden of cancer. However, the efficacy of risk information frameworks supplied to consumers in expanding CDI coverage remains poorly understood.PurposeThis study
Zhenyu Sun +7 more
doaj +1 more source
Contemporary Social Sciences, 2021 The European Union (EU) seeks to build a Europe fit for the digital age. For this purpose, the EU has accelerated the process of catching up with digital technology and issued a number of legal and regulatory documents to establish a digital ...
Yan Guang and Tian Hongyu
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Conducting marine genetic research for whom? Mapping knowledge flows from science to patents
npj Ocean SustainabilityMarine genetic resources hold great value for biotechnological innovation and sustainability-oriented research. However, studies indicate that intellectual property rights pertaining to these resources are concentrated in a handful of companies and ...
Paul Dunshirn, Erik Zhivkoplias
doaj +1 more source
Frontiers in Digital HealthThis study aims to leverage the advanced capabilities of quantum computing to construct an efficient framework for processing large-scale health data, uncover potential higher-order correlations in medicine, and enhance the accuracy of smart healthcare ...
Peng Mei, Fuquan Zhang
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Digital Governance for Sustainable Development [PDF]
, 2017 This lecture discusses the impact of digital transformation of governance mechanisms as a tool to promote sustainable development and more inclusive societies, in the spirit of the United Nations 2030 Agenda. Three main challenges are addressed: the pursuit of inclusiveness, trustworthiness of software infrastructures, and the mechanisms to enforce ...
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source