Results 51 to 60 of about 568,230 (309)

Digital government and transformation [PDF]

open access: yes, 2021
The last two decades have seen a rapid societal transformation in the way information is processed and consumed. Digital technologies are now playing a catalyzing role in the digitization of services to citizens and are being used in multiple functions ...
UN.ESCAP   +1 more
core  

Pelayanan izin usaha secara one single submission di Aceh Barat

open access: yesJAKP (Jurnal Administrasi dan Kebijakan Publik), 2021
T The article talks about the electronic business license service provided by the One Single Submission (OSS) application, which has been implemented at the West Aceh Regency's Office of Investment and One Stop Integrated Services (DPMPTSP).
Dista Setyaningsih   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Open Source for Digital Curation [PDF]

open access: yes, 2005
This Curation Manual instalment discusses at some lengths the relevant strengths of open source software from a digital curation perspective, as well as detailing some of its more general advantages, which must be understood in order to accept the ...
McHugh, Mr Andrew, McHugh, Andrew
core  

Examining the socio-economic determinants of adoption of the 'Government Gateway' initiative in the UK

open access: yes, 2006
This paper empirically examines the impact of socio-economic determinants upon the adoption of a recent UK e-government initiative, the 'Government Gateway'. The data on five socio-economic characteristics was collected employing a postal survey.
Dwivedi, YK   +4 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Examining Digital Government Maturity Models: Evaluating the Inclusion of Citizens

open access: yesAdministrative Sciences
Digital transformation affects nearly every sector of society and is seen as a strategic approach to addressing evolving demands, including those of citizens, demographic shifts, and skill shortages.
Åsa Waara
doaj   +1 more source

Eventuality issues of digital transformation of socio-economic systems

open access: yesE-Management, 2023
The article examines the possible prospects for the development of the Russian economy due to the intensification of the processes of digital transformation.
N. S. Kozyr
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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