Results 61 to 70 of about 568,230 (309)

Digital Governance for Sustainable Development [PDF]

, 2017
This lecture discusses the impact of digital transformation of governance mechanisms as a tool to promote sustainable development and more inclusive societies, in the spirit of the United Nations 2030 Agenda. Three main challenges are addressed: the pursuit of inclusiveness, trustworthiness of software infrastructures, and the mechanisms to enforce ...
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Digital Government and Open Data Readiness Assessment

, 2019
This report, composed of two separate themes of Digital Government Readiness Assessment (DGRA) and Open Data Readiness Assessment (ODRA), is intended to help government assess their digital environments and frame ...
Government of Vietnam, World Bank
core   +1 more source

AI Readiness Level in Public Administration: Case of the Russian Federation

RUDN Journal of Public Administration
The study explores approaches to the analysis of measurable indicators of artificial intelligence and its use in the system of sectoral public administration.
Roman S. Stupin
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

E-Government and the digital divide

, 2008
Many governments world wide are attempting to increase accountability, transparency, and the quality of services by adopting information and communications technologies (ICTs) to modernize and change the way their administrations work.
Yigitcanlar, Tan, Scott Baum, Baum, Scott, Tan Yigitcanlar   +3 more
core   +1 more source

GOVERNMANET PUBLIC RELATIONS IN FACING POLITICAL YEAR: TRAINING FOR LOCAL GOVERNMENT OF MAGETAN

Jurnal Layanan Masyarakat (Journal of Public Services)
The issues faced by Indonesia in the 2019 elections are likely to reemerge in the 2024 elections. In the 2019 elections, digital media became a highly effective tool for disseminating information related to politics and governance. Unfortunately, not all
Rani Sukma Ayu Suteja, Titik Puji Rahayu, Irfan Wahyudi, Suko Widodo, Dina Septiani, Santi Isnaini, Intan Fitranisa, Ratih Puspa   +7 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Digital Government Ecosystem: Adaptive Architecture for Digital and ICT Investment Decision Making [PDF]

Agencies, while operating in the federated digital government ecosystem, need to make significant investments in digital and information and communication technology (ICT) for providing services to people and businesses.
Gill, A, Hansnata, M
core   +1 more source