Results 61 to 70 of about 3,077,379 (274)

Can technology increase COVID-19 vaccination rates?

open access: yesThe Lancet: Digital Health, 2021
The Lancet Digital Health
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Online outsiders within\ud [PDF]

open access: yes, 2010
Heightened attention to technological diffusion and informational inequalities is of\ud particular societal concern, given the increasing mediation of everyday life whereby\ud web-based initiatives abound and an increasing amount of information on ...
Cheong, Pauline Hope, Martin, Judith
core  

Firsthand Opiates Abuse on Social Media: Monitoring Geospatial Patterns of Interest Through a Digital Cohort [PDF]

open access: yes, 2019
In the last decade drug overdose deaths reached staggering proportions in the US. Besides the raw yearly deaths count that is worrisome per se, an alarming picture comes from the steep acceleration of such rate that increased by 21% from 2015 to 2016 ...
Bajardi, Paolo   +2 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A Patient-Centered Framework for Evaluating Digital Maturity of Health Services: A Systematic Review [PDF]

open access: yes, 2015
© Kelsey Flott, Ryan Callahan, Ara Darzi, Erik Mayer.Background: Digital maturity is the extent to which digital technologies are used as enablers to deliver a high-quality health service. Extensive literature exists about how to assess the components of
Callahan, R   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A decision support tool for supporting individuals living with long-term conditions make informed choices: LTC-Choices tool for continuous healthcare [PDF]

open access: yes, 2018
An increasing number of individuals are now living with some form of chronic, long-term condition (LTC). The holistic perspective of LTCs makes it important to acknowledge that priorities and decisions are in fluctuation over the course of an individual ...
Burstein, Frada, Cowie, Julie
core   +2 more sources

Race representation matters in cancer care

open access: yesThe Lancet: Digital Health, 2021
The Lancet Digital Health
doaj   +1 more source

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