Label-Free Classification of Apoptosis, Ferroptosis and Necroptosis Using Digital Holographic Cytometry [PDF]
Applied Sciences, 2020 Apoptosis, ferroptosis and necroptosis are three distinct forms of programmed cell death. Each of these pathways can be exploited to terminate cancer cells.
Kendra L. Barker +2 more
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Quantifying the Rate, Degree, and Heterogeneity of Morphological Change during an Epithelial to Mesenchymal Transition Using Digital Holographic Cytometry [PDF]
Applied Sciences, 2020 Cells in complex organisms can transition between epithelial and mesenchymal phenotypes during both normal and malignant physiological events. These two phenotypes are not binary, but rather describe a spectrum of cell states along an axis.
Sofia Kamlund +4 more
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Evaluation of the Impact of Imprinted Polymer Particles on Morphology and Motility of Breast Cancer Cells by Using Digital Holographic Cytometry [PDF]
Applied Sciences, 2020 Breast cancer is the second most common cancer type worldwide and breast cancer metastasis accounts for the majority of breast cancer-related deaths. Tumour cells produce increased levels of sialic acid (SA) that terminates the monosaccharide on glycan ...
Megha Patel +4 more
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Photonics, 2022 Colorectal cancer (CRC) is the second most metastatic disease with the majority of cases detected in Western countries. Metastases are formed by circulating altered phenotype tumor cells causing 20% of CRC related deaths. Metastatic cells may show higher
Marek Feith +5 more
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Discrimination between Breast Cancer Cells and White Blood Cells by Non-Invasive Measurements: Implications for a Novel In Vitro-Based Circulating Tumor Cell Model Using Digital Holographic Cytometry [PDF]
Applied Sciences, 2020 Breast cancer is the second most common cancer worldwide. Metastasis is the main reason for death in breast cancer, and today, there is a lack of methods to detect and isolate circulating tumor cells (CTCs), mainly due to their heterogeneity and rarity ...
Zahra El-Schich +5 more
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Label-Free Analysis of Urine Samples with In-Flow Digital Holographic Microscopy [PDF]
Biosensors, 2023 Urinary tract infections are among the most frequent infectious diseases and require screening a great amount of urine samples from patients. However, a high percentage of samples result as negative after urine culture plate tests (CPTs), demanding a ...
Lucia Gigli +4 more
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Spatial microfluidic holographic integrated platform for label-free and high-dimensional analysis of cancer heterogeneity [PDF]
Nature CommunicationsThe combination of quantitative phase microscopy (QPM) with imaging flow cytometry (IFC) enables label-free and multi-parameter single-cell analysis. Here, we present a simple yet powerful QPM-IFC platform, the spatial microfluidic holographic integrated
Jiayi Shi +9 more
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On-chip label-free cell classification based directly on off-axis holograms and spatial-frequency-invariant deep learning [PDF]
Scientific Reports, 2023 We present a rapid label-free imaging flow cytometry and cell classification approach based directly on raw digital holograms. Off-axis holography enables real-time acquisition of cells during rapid flow.
Matan Dudaie +3 more
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Label-free detection of ovarian cancer cells in ascites-related cell models using digital holographic flow cytometry [PDF]
Biomedical Optics ExpressOvarian cancer is one of the most lethal gynecological malignancies, frequently accompanied by ascites formation in advanced stages. Accurate identification of ovarian cancer cells within ascitic fluid is clinically important yet technically challenging due to pronounced cellular heterogeneity. Here, we establish a quantitative holographic imaging flow
Yijing Li +4 more
openaire +2 more sources
A dynamic study of VEGF-A siDOX-EVs trafficking through the in-vitro insert co-culture blood-brain barrier model by digital holographic microscopy [PDF]
Frontiers in OncologyIntroductionModeling the blood-brain barrier has long been a challenge for pharmacological studies. Up to the present, numerous attempts have been devoted to recapitulating the endothelial barrier in vitro to assess drug delivery vehicles’ efficiency for
Parisa Shamshiripour +9 more
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