Results 101 to 110 of about 3,232,610 (341)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Keynote 3

open access: yesPakistan Journal of Information Management & Libraries, 2016
This paper addresses the relationship between Digital Libraries (DL) and Digital Humanities (DH) with a special focus on global access to knowledge. An overview DL & DH and their interconnections are described.
Widad El Hadi
doaj  

A Digital 4D Information System on the World Scale: Research Challenges, Approaches, and Preliminary Results

open access: yesApplied Sciences
Numerous digital media repositories have been set up during recent decades, each containing plenty of data about historic cityscapes. In contrast, digital 3D reconstructions of no longer extant cityscapes have so far almost solely been performed for ...
Sander Münster   +9 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

DIGITAL HUMANITIES IN HIGHER EDUCATION SYSTEM OF CANADA

open access: yesНеперервна професійна освіта: теорія та практика, 2019
The urgency of the article is due to the increased impact of information and communication technologies on research in the field of socio-humanitarian cycle sciences, which led to the emergence of interdisciplinary direction of research and projects ...
Olena Voskoboinikova-Huzieva
doaj   +1 more source

Corpus Linguistics and Digital Humanities. Intersecting Paths. A Case Study from Twitter

open access: yesAmérica Crítica, 2020
In this paper I aim at critically discussing the role of Corpus Linguistics within the field of Digital Humanities. I posit that the accessible and user-friendly tools of Corpus Linguistics are an optimal resource for scholars within the Humanities and ...
Angela Zottola
doaj   +1 more source

Digital Humanities in the Anthropocene [PDF]

open access: yesDigital Scholarship in the Humanities, 2015
This keynote address for the 2014 Digital Humanities conference is a practitioner’s talk, and—though the abstract belies it—an optimistic one. I take as given the evidence that human beings are irrevocably altering the conditions for life on Earth and that, despite certain unpredictabilities, we live at the cusp of a mass extinction.
openaire   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Digital Humanism

open access: yes, 2022
This open access book deals with cultural and philosophical aspects of artificial intelligence (AI) and pleads for a “digital humanism”. This term is beginning to be en vogue everywhere. Due to a growing discontentment with the way digitalization is being used in the world, particularly formulated by former heroes of Internet, social media and search ...
Nida-Rümelin, Julian   +1 more
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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