Results 91 to 100 of about 451,596 (341)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Evolutionary Subject Tagging in the Humanities; Supporting Discovery and Examination in Digital Cultural Landscapes [PDF]

, 2011
In this paper, the authors attempt to identify problematic issues for subject tagging in the humanities, particularly those associated with information objects in digital formats.
Ammerman, Jack, Benedetti, Dan, Green, Garth W., Zafrin, Vika   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Becoming the Gothic Archive: From Digital Collection to Digital Humanities [PDF]

, 2015
The Gothic Archive is the flagship digital humanities project for the Marquette University library. The project was birthed from a simple digital collection, and through the partnership of faculty and librarians, was transformed into something more.
Fortier, Rose, James, Heather G.
core   +1 more source

Annotation of subtitle paraphrases using a new web tool

Digital Humanities in the Nordic and Baltic Countries Publications, 2019
This paper analyzes the manual annotation effort carried out to produce Opusparcus, the Open Subtitles Paraphrase Corpus for six European languages. Within the scope of the project, a new web-based annotation tool was created.
Mikko Aulamo, Mathias Creutz, Eetu Sjöblom   +2 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Archaeology in the Digital Age: From Paper to Databases

, 2015
Research units in archaeology often manage large and precious archives containing various documents, including reports on fieldwork, scholarly studies and reference books.
Ferguth, Johan, Gruel, Katherine, Mélanie-Becquet, Frédérique, Poibeau, Thierry   +3 more
core  

Present, Not Voting: Digital Humanities in the Panopticon: Closing Plenary Speech, Digital Humanities 2010 [PDF]

, 2010
Digital Humanities faces many issues in the current financial and educational climate. In this closing plenary from the Digital Humanities conference 2010 at King’s College London, major concerns about the current role and function of Digital Humanities ...
TERRAS, M
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Open Digital Humanities

Digital Humanities in the Nordic and Baltic Countries Publications, 2018
One of the strong instruments for the promotion of Open Science in Digital Humanities is research infrastructures. PARTHENOS is a European research infrastructure project, basically built upon collaboration between two large the research ...
Bente Maegaard
doaj   +1 more source