Results 91 to 100 of about 3,232,610 (341)

Teaching Libraries zwischen Vermittlung fachwissenschaftlicher Informationskompetenz und der Unterstützung einer Propädeutik für die Digital Humanities

o-bib. Das offene Bibliotheksjournal, 2017
Der Beitrag geht von der Beobachtung aus, dass Bibliotheken bisher zwar die Themen E‑Science und Forschungsdaten in ihre Überlegungen hinsichtlich spezifischer Angebote zur Informationskompetenz einbezogen haben. Aber obwohl Bibliotheken über ein breites
Marcus Schröter
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Alliance for Digital Humanities Organizations Digital Humanities Conference Calls for Papers 2015-2020 Collection

, 2020
Individual authorship is not recorded.Collection of English-language calls for papers for the Annual Digital Humanities Conference sponsored by the Alliance for Digital Humanities Organizations from 2015 ...
Alliance for Digital Humanities Organizations
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Introduction: Integrating Digital Humanities [PDF]

, 2019
Introduction to the inaugural issue of the DH Benelux Journal which explores the theme of Integrating Digital ...
Birkholz, Julie, ZAAGSMA, Gerben, Birkholz, Julie M.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Visualization in digital humanities

大数据, 2022
The development of information technology has promoted the generation of a new scientific research paradigm.Social sciences and humanities have gradually developed a data-driven research method in recent years.From the perspective of visualization, the ...
Yuchu LUO, Hao WU, Yuhan GUO, Shaocong TAN, Can LIU, Ruike JIANG, Xiaoru YUAN   +6 more
doaj  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Descriptive markup languages and the development of digital humanities

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The paper discusses the role of descriptive markup languages in the development of digital humanities, a new research discipline that is part of social sciences and humanities, which focuses on the use of computers in research.
Boris Bosančić
doaj   +1 more source

Information seeking by humanities scholars

, 2005
This paper investigates the information seeking of humanities academics and scholars using digital libraries. It furthers existing work by updating our knowledge of the information seeking techniques used by humanities scholars, where the current work ...
Rimmer, J, Ann Bl, Buchanan, G., Cunningham, SJ, Warwick, C., Jon Rimmer, Warwick, C, Claire Warwick, Rimmer, J., Buchanan, G, Blandford, A, Sally Jo Cunningham, Cunningham, S.J., Ann Blandford, George Buchanan, Blandford, A.   +15 more
core   +1 more source