Results 71 to 80 of about 4,903 (217)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Annotation of subtitle paraphrases using a new web tool
Digital Humanities in the Nordic and Baltic Countries Publications, 2019 This paper analyzes the manual annotation effort carried out to produce Opusparcus, the Open Subtitles Paraphrase Corpus for six European languages. Within the scope of the project, a new web-based annotation tool was created.
Mikko Aulamo +2 more
doaj +1 more source
Sustaining Digital Humanities Collections: Challenges and Community-Centred Strategies
International Journal of Digital Curation, 2020 Since the advent of digital scholarship in the humanities, decades of extensive, distributed scholarly efforts have produced a digital scholarly record that is increasingly scattered, heterogeneous, and independent of curatorial institutions.
Katrina Simone Fenlon
doaj +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Digital Humanities and AI Ethics
مجلة العلوم و آفاق المعارفThis article offers an in-depth review of Chapter Forty-Two, 'Artificial Intelligence, Ethics, and Digital Humanities', from 'The Bloomsbury Handbook of Digital Humanities' (2023).
Hassina Benreguia, David Berry
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Digital Humanities in the Nordic and Baltic Countries Publications, 2018 One of the strong instruments for the promotion of Open Science in Digital Humanities is research infrastructures. PARTHENOS is a European research infrastructure project, basically built upon collaboration between two large the research ...
Bente Maegaard
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Lecture: Getting from here to there
MedieKultur: Journal of Media and Communication Research, 2014 Based on his keynote lecture at the international conference on Digital Humanities at Aalborg University in April 2014, John Naughton refl ects on being an engineer in a Humanities research institute that is currently seeking to adapt to the digital ...
John Naughton
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