Results 51 to 60 of about 35,760,262 (245)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Reception Reader: Exploring Text Reuse in Early Modern British Publications

Journal of Open Humanities Data, 2023
The Reception Reader is a web tool for studying text reuse in the Early English Books Online (EEBO-TCP) and Eighteenth Century Collections Online (ECCO) data. Users can: 1) explore a visual overview of the reception of a work, or its incoming connections,
David Rosson, Eetu Mäkelä, Ville Vaara, Ananth Mahadevan, Yann Ryan, Mikko Tolonen   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Digital storytelling: New opportunities for humanities scholarship and pedagogy

Cogent Arts & Humanities, 2016
At first thought, combining storytelling, digital tools, and humanities seems improbable. For example, digital storytelling is characterized by interactivity, nonlinearity, flexible outcomes, user participation, even co-creation.
John F. Barber
doaj   +1 more source

The Literary And/As the Digital Humanities

Digital Humanities Quarterly, 2013
This essay introduces a special issue on The Literary.
Jessica Pressman, Lisa Swanstrom
openaire   +2 more sources

The Humanities in the Digital: Beyond Critical Digital Humanities [PDF]

, 2023
This open access book challenges the contemporary relevance of the current model of knowledge production. It argues that the full digitisation of society sharply accelerated by the COVID-19 pandemic has added extreme complexity to the world, conclusively exposing the inadequacy of our current model of knowledge creation.
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mapping Visions of Rome and Digital Roman Heritage Connectivity between Literary and Artistic Heritage in a Digital Age

Umanistica Digitale, 2018
This paper introduces two projects in the realm of Digital Humanities, Mapping Visions of Rome and Digital Roman Heritage. The first project was conceived as a digital aid to my traditional research, while the second developed as a digital aid to the ...
Susanna de Beer
doaj   +1 more source

What Is It Like to Make a Prototype? Practitioner Reflections on the Intersection of User Experience and Digital Humanities/Social Sciences during the Design and Delivery of the “Getting to Mount Resilience” Prototype

Informatics, 2023
The digital humanities and social sciences are critical for addressing societal challenges such as climate change and disaster risk reduction. One way in which the digital humanities and social sciences add value, particularly in an increasingly ...
Ashlin Lee
doaj   +1 more source