Results 51 to 60 of about 451,596 (341)

Mapping Visions of Rome and Digital Roman Heritage Connectivity between Literary and Artistic Heritage in a Digital Age

Umanistica Digitale, 2018
This paper introduces two projects in the realm of Digital Humanities, Mapping Visions of Rome and Digital Roman Heritage. The first project was conceived as a digital aid to my traditional research, while the second developed as a digital aid to the ...
Susanna de Beer
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Post-digital humanities: computation and cultural critique in the arts and humanities [PDF]

, 2014
Today we live in computational abundance whereby our everyday lives and the environment that surrounds us are suffused with digital technologies. This is a world of anticipatory technology and contextual computing that uses smart diffused computational ...
Berry, David M
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Agilität, Versionierung und Open Source. Softwareentwicklung und Praktiken der Geisteswissenschaften

Zeitschrift für digitale Geisteswissenschaften, 2018
The Digital Humanities open up the possibility to access literary and historical sources in new ways. They enable the large-scale data analysis of cultural artifacts, which can be understood as the ...
Arndt Niebisch
doaj   +1 more source

What Is It Like to Make a Prototype? Practitioner Reflections on the Intersection of User Experience and Digital Humanities/Social Sciences during the Design and Delivery of the “Getting to Mount Resilience” Prototype

Informatics, 2023
The digital humanities and social sciences are critical for addressing societal challenges such as climate change and disaster risk reduction. One way in which the digital humanities and social sciences add value, particularly in an increasingly ...
Ashlin Lee
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Digital Humanities Data Curation [PDF]

, 2016
Digital Humanities Data Curation (DHDC) will engage scholars in sustained collaboration around issues of data curation in order to educate scholars on best practices and technologies for data curation and their relationship to scholarly methods.
Julia Hammond Flanders, Julia Hammond Flanders, Megan Senseney, Megan Senseney, Trevor Muñoz, Trevor Muñoz   +5 more
core   +1 more source

Reception Reader: Exploring Text Reuse in Early Modern British Publications

Journal of Open Humanities Data, 2023
The Reception Reader is a web tool for studying text reuse in the Early English Books Online (EEBO-TCP) and Eighteenth Century Collections Online (ECCO) data. Users can: 1) explore a visual overview of the reception of a work, or its incoming connections,
David Rosson, Eetu Mäkelä, Ville Vaara, Ananth Mahadevan, Yann Ryan, Mikko Tolonen   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source