Results 51 to 60 of about 4,903 (217)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Humanities Computing as Digital Humanities
Digital Humanities Quarterly, 2009 This article presents an examination of how digital humanities is currently conceived and described, and examines the discursive shift from humanities computing to digital humanities. It is argued that this renaming of humanities computing as digital humanities carries with it a set of epistemic commitments that are not necessarily compatible with a ...
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
o-bib. Das offene Bibliotheksjournal, 2017 Der Beitrag geht von der Beobachtung aus, dass Bibliotheken bisher zwar die Themen E‑Science und Forschungsdaten in ihre Überlegungen hinsichtlich spezifischer Angebote zur Informationskompetenz einbezogen haben. Aber obwohl Bibliotheken über ein breites
Marcus Schröter
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Visualization in digital humanities
大数据, 2022 The development of information technology has promoted the generation of a new scientific research paradigm.Social sciences and humanities have gradually developed a data-driven research method in recent years.From the perspective of visualization, the ...
Yuchu LUO +6 more
doaj
Descriptive markup languages and the development of digital humanities
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012 The paper discusses the role of descriptive markup languages in the development of digital humanities, a new research discipline that is part of social sciences and humanities, which focuses on the use of computers in research.
Boris Bosančić
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, 2022 This open access book deals with cultural and philosophical aspects of artificial intelligence (AI) and pleads for a “digital humanism”. This term is beginning to be en vogue everywhere. Due to a growing discontentment with the way digitalization is being used in the world, particularly formulated by former heroes of Internet, social media and search ...
Nida-Rümelin, Julian +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source