Results 41 to 50 of about 4,903 (217)
Digital Humanities in the Anthropocene [PDF]
Digital Scholarship in the Humanities, 2015 This keynote address for the 2014 Digital Humanities conference is a practitioner’s talk, and—though the abstract belies it—an optimistic one. I take as given the evidence that human beings are irrevocably altering the conditions for life on Earth and that, despite certain unpredictabilities, we live at the cusp of a mass extinction.
openaire +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Informatics, 2023 The digital humanities and social sciences are critical for addressing societal challenges such as climate change and disaster risk reduction. One way in which the digital humanities and social sciences add value, particularly in an increasingly ...
Ashlin Lee
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Reception Reader: Exploring Text Reuse in Early Modern British Publications
Journal of Open Humanities Data, 2023 The Reception Reader is a web tool for studying text reuse in the Early English Books Online (EEBO-TCP) and Eighteenth Century Collections Online (ECCO) data. Users can: 1) explore a visual overview of the reception of a work, or its incoming connections,
David Rosson +5 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Agilität, Versionierung und Open Source. Softwareentwicklung und Praktiken der Geisteswissenschaften
Zeitschrift für digitale Geisteswissenschaften, 2018 The Digital Humanities open up the possibility to access literary and historical sources in new ways. They enable the large-scale data analysis of cultural artifacts, which can be understood as the ...
Arndt Niebisch
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Introduction: Digital Humanities, Public Humanities
NANO, 2014 NANO: New American Notes Online: An Interdisciplinary Academic Journal for Big Ideas in a Small World. This special issue shows how both public and digital humanities research can be rendered more persuasive through engagement with cultures beyond the ...
Alex Christie +3 more
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