Results 71 to 80 of about 2,120,742 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On Matching Skulls to Digital Face Images: A Preliminary Approach

open access: yes, 2017
Forensic application of automatically matching skull with face images is an important research area linking biometrics with practical applications in forensics.
Jain, Arushi   +5 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Assessment of Reliability of Three Different Computer-Assisted Analysis Programs

open access: yesTurkish Journal of Orthodontics, 2013
Objective:The aim of this study was to assess the reliability of cephalometric analysis using 3 different digital analysis programs.Methods:For this study, a dry human skull with the entire mandible, maxilla, and teeth was used.
Ebubekir Toy   +3 more
doaj   +1 more source

Digital enhancement of flow field images [PDF]

open access: yes
Most photographs of experimentally generated fluid flow fields have inherently poor photographic quality, specifically low contrast. Thus, there is a need to establish a process for quickly and accurately enhancing these photographs to provide improved ...
Kudlinski, Robert A., Park, Stephen K.
core   +1 more source

Species-specific forest variable estimation using non-parametric modeling of multi-spectral photogrammetric point cloud data [PDF]

open access: yes, 2012
The recent development in software for automatic photogrammetric processing of multispectral aerial imagery, and the growing nation-wide availability of Digital Elevation Model (DEM) data, are about to revolutionize data capture for forest management ...
Bohlin, Jonas   +3 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Adaptive Filters for 2-D and 3-D Digital Images Processing [PDF]

open access: yes, 2012
Práce se zabývá adaptivními filtry pro vizualizaci obrazů s vysokým rozlišením. V teoretické části je popsán princip činnosti konfokálního mikroskopu a matematicky korektně zaveden pojem digitální obraz.
Martišek, Karel
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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