Results 61 to 70 of about 54,970 (293)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluation of digital and traditional impressions in orthodontics: a narrative review

Annali di Stomatologia
Objective: This narrative review explores the clinical, technical, and patient-centered differences between digital and traditional dental impression techniques, focusing on their role in orthodontics.
Sabina Saccomanno, Lorenzo Ederli Silenzi, Mario Palermiti, Simone Ettore Salvati, Daniela Di Giandomenico, Eda Fani, Giuseppe Marzo   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Digital vs analog dental impression [PDF]

, 2018
Introduction: For the preparation of one good and functional prosthetic preparation, it is necessary to make an appropriate and good tissue imprint from the tissues in the patient's mouth.
Tileva, Slavica, Toneva Stojmenova, Verica, Dejkoska, Magdalena, Kocovski, Darko   +3 more
core  

Marginal and internal fit accuracy of single-crown restorations: the impact of digital and conventional impression techniques

BMC Oral Health
Background In this study, we aimed to compare the marginal and internal fit of single-crown restorations fabricated using digital and conventional impression techniques, and to evaluate the potential advantages of digital impressions over conventional ...
Basak Topdagi, Ceren Cakar Guler, Elifnur Guzelce Sultanoglu   +2 more
doaj   +1 more source

Era of Digital Impressions

, 2023
Impressions are considered to be an important aspect of prosthodontics. They have various applications, from fabricating casts or patient education to production of final or interim prosthesis. In the twenty first century where, artificial intelligence is slowly replacing conventional methods, digital impression systems are gaining popularity.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dental Students' Perceptions of Digital and Conventional Impression Techniques: A Randomized Controlled Trial.

, 2017
The aim of this randomized controlled trial was to analyze inexperienced dental students' perceptions of the difficulty and applicability of digital and conventional implant impressions and their preferences including performance.
Dedem, Philipp, Joda, Tim Alexander, Nicola U. Zitzmann, Lenherr, Patrik, Philipp Dedem, Zitzmann, Nicola U, Kovaltschuk, Irina, Irina Kovaltschuk, Tim Joda, Patrik Lenherr   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Institutional Shaping of Cultural Memory: Digital Library as Environment for Textual Transmission [PDF]

, 2004
The emerging trends in digital(ized) collection development from 1997 are examined using a sample of projects accessible through web-based registries of the Association of Research Libraries and Digital Library Federation.
Dalbello, Marija
core