Results 41 to 50 of about 2,644,704 (272)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Pixel-Bit, 2023 Digital exclusion is a challenging phenomenon in many countries. The low level of digital and media competences among senior citizens raises many questions about the effectiveness of existing digital inclusion activities.
Lukasz Tomczyk +3 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Digital inclusion - the vision, the challenges and the way forward [PDF]
, 2015 This paper considers the vision and aspiration of digital inclusion, and then examines the current reality. It looks beyond the rhetoric to provide an analysis of the status quo, a consideration of some facilitators and challenges to progress and some ...
Craig, M +4 more
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Inclusion meets Digitalization.
Ludwigsburger Beiträge zur Medienpädagogik, 2021 Im Kontext „Schule“ wurden zwar (u. a. coronabedingt) zunehmend technisch-infrastrukturelleVoraussetzungen für den Einsatz digitaler Medien geschaffen, aber das Potential des digitalen Wandelsim Kontext „Inklusion/Umgang mit Heterogenität“ für chancengerechtes, individualisiertes Lernen im inklusiven Schulkontext wird kaum ausgeschöpft.
Claudia Mertens, Kathrin Friesen
openaire +2 more sources
Acousto-optical coherence tomography with a digital holographic detection scheme [PDF]
, 2012 Acousto-optical coherence tomography (AOCT) consists in using random phase jumps on ultrasound and light to achieve a millimeter resolution when imaging thick scattering media. We combined this technique with heterodyne off-axis digital holography.
Benoit, Emilie +4 more
core +5 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Digital Literacy Key Performance Indicators for Sustainable Development
Social Inclusion, 2020 The concept of digital literacy has been defined in numerous ways over the last two decades to incorporate rapid technological changes, its versatility, and to bridge the global digital divide.
Danica Radovanović +8 more
doaj +1 more source