Results 51 to 60 of about 8,762 (202)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
DETERMINANT OF DIGITAL FINANCIAL INCLUSION ADOPTION IN SUB SAHARAN AFRICA
Malete Journal of Accounting and FinanceFinancial exclusion remains a major global challenges, particularly in developing economies, where a large proportion of the population still lacks access to digital financial services due to limited internet penetration and infrastructure deficits ...
Biliqees Ayoola Abdulmumin
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
AI-Driven Inclusion in Romanian Preuniversity Education: A Mixed-Methods Study
Journal of Digital PedagogyThis study investigates how artificial intelligence (AI) and digital transformation shape inclusion and equity in Romania's preuniversity education system. Using a sequential explanatory mixed-methods design, we surveyed 362 teachers, school leaders, and
Cristina-Georgiana Voicu
doaj +1 more source
Digital Literacy Key Performance Indicators for Sustainable Development
Social Inclusion, 2020 The concept of digital literacy has been defined in numerous ways over the last two decades to incorporate rapid technological changes, its versatility, and to bridge the global digital divide.
Danica Radovanović +8 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
‘e-fatura’ - Estudo misto com participantes Seniores num projeto Municipal em Viseu
Páginas a&b, 2020 The use of Information and Communication Technologies (ICT) is now democratized in the information society, however there are some age brackets that use less, such as senior citizens over the age of 65. Although the use of ICT among the senior population
Manuel Monteiro Barbosa +1 more
doaj +1 more source