Results 31 to 40 of about 4,106,840 (326)

Assessing the Components of Information Security in Accessing & Use of Digital Libraries

Iranian Journal of Information Processing & Management, 2021
Information security is one of the effective factors in protecting and using digital libraries which can help improve the status of these libraries.This research reviews the accessibility to information security of digital libraries in digital libraries ...
Fariborz Doroudi, Zeinab Jamshidi
doaj  

Convergence of digital humanities and digital libraries

, 2015
Purpose – Digital humanities (DH) has become a much discussed topic among both humanities scholars and library professionals. The library and information science (LIS) community has taken efforts in providing new facilities and developing new services to
Y. Zhang, Shu Liu, E. Mathews
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Duplicate Literature Detection for Cross-Library Search

Cybernetics and Information Technologies, 2016
The proliferation of online digital libraries offers users a great opportunity to search their desired literatures on Web. Cross-library search applications can help users search more literature information from multiple digital libraries.
Liu Wei, Zeng Jianxun
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Service Review of Digital Libraries in Iran and in the World: Proposed Services for Digital Libraries in Iran [PDF]

تحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2010
Objective: The present paper investigates the existing services offerd by digital libraries in Iran and around the world in order to introduce proposed services for Iranian digital libraries Methodoloy: A comparative and adaptive method was used.
yaghoub Norouzi, B Bayat
doaj  

Creating Digital Identity for Arabic National Libraries from Content Analysis of Missions & Vision Statements Using Machine Learning Algorithms. [PDF]

المجلة المصرية لعلوم المعلومات
Creating Digital Identity for Arabic National Libraries from Content Analysis of Missions & Vision Statements Using Machine Learning Algorithms.This study explores the utilization of ML content analysis algorithms to create a robust digital identity for ...
مؤمن سيد النشرتي النشرتيي
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source