Results 31 to 40 of about 584,239 (266)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Organisation management in the digital economy: graduation according to the degree of using digital technologies

Вестник университета
The active introduction of   digital technologies by   business entities does not only rapidly change their external and internal environments, but also affects the essence of   the economy, forming qualitative structural transformations in   it, which ...
A. V. Veretyokhin
doaj   +1 more source

Universally Composable Oblivious Transfer with Low Communication

Applied Sciences, 2023
In this paper, a universally composable 1-out-of-N oblivious transfer protocol with low communication is built. This protocol obtained full simulation security based on the modulo learning with rounding (Mod-LWR) assumption.
Jiashuo Song, Dongfei Wang, Zhenzhen Zhang, Zhenzhen Li, Haiyang Ding, Zichen Li   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Can Post-Retirement Work Always Prevent Depression?

Behavioral Sciences, 2023
Given the rising popularity of post-retirement work and its potential benefits for older adults’ mental health, this study examined older adults’ adaptation ability as a conditional factor for the impact of post-retirement work on depression ...
Haiting Yan, Juan Liu, Wei Wei, Hongyan Xu, Xu Huang, Jiaxin Ying   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Contemporary Asian experience of digitalization and sustainable development in economy and management. A review of the book “Business and management in Asia: digital innovation and sustainability” (Springer, 2023)

E-Management
Entering the markets of Asian countries and developing cooperation with their business structures are important tasks, which makes it relevant to study current trends in economic and management changes in these countries.
D. A. Ruban
doaj   +1 more source

DIGITAL FARMING – DIGITAL MANAGEMENT

Annals of the Polish Association of Agricultural and Agribusiness Economists, 2018
Digitalization of farm machines and production processes in agriculture is progressing very dynamically. Therefore, farm processes management must use the available data, which allow making decisions in an optimal way, using current as well as historical data. The paper presents the latest trends related to the digitization of processes in agriculture.
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Scenario approach in forecast assessment of balanced development of regional socio-economic system and its growth points determination

Вестник университета
In-depth examination of the developing an organizational and economic mechanism concept aimed at ensuring regional socio-economic system balance under conditions of active digital transformation has been carried out.
A. V. Ivanchenkov
doaj   +1 more source