Results 51 to 60 of about 84,502 (290)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
MATEC Web of Conferences, 2017 A framework of non-intrusive polynomial chaos expansion method (PC) was proposed to investigate the statistic characteristics of the response of structural-acoustic system containing random uncertainty.
Wang Mingjie +4 more
doaj +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Powder-Based 3D Printing for the Fabrication of Device with Micro and Mesoscale Features
Micromachines, 2020 Customized manufacturing of a miniaturized device with micro and mesoscale features is a key requirement of mechanical, electrical, electronic and medical devices.
Seow Yong Chin +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Distributed Manufacturing Systems with Digital Agent
Strojniški vestnik – Journal of Mechanical Engineering, 2019 This paper presents a novel approach to implement manufacturing nodes using the combined strength of digital twins, holons, and digital agents. Manufacturing nodes are based on holon theory and present a universal manufacturing platform that consists of cyber-physical systems (CPS) with an integrated digital twin, digital agent, databases and various ...
Herakovič, Niko +4 more
openaire +2 more sources
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
A model on the curved shapes of unsymmetric laminates including tool-part interaction
Science and Engineering of Composite Materials, 2018 The room-temperature shape of unsymmetric laminate due to the residual stress developed during the curing process has been investigated in the past decades.
Yuan Zhenyi +7 more
doaj +1 more source
IEEE Access, 2019 Printed circuit board (PCB) assembly lines are significant to produce a variety of electronic products. PCB manufacturing industries tend to move towards automated and complex manufacturing system due to an increase in the customer demand for more ...
Jabir Mumtaz +5 more
doaj +1 more source