Results 1 to 10 of about 2,871,670 (306)

Drug screening on digital microfluidics for cancer precision medicine. [PDF]

Nat Commun
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage cancer, has hindered the widespread application
Zhai J, Liu Y, Ji W, Huang X, Wang P, Li Y, Li H, Wong AH, Zhou X, Chen P, Wang L, Yang N, Chen C, Chen H, Mak PI, Deng CX, Martins R, Yang M, Ho TY, Yi S, Yao H, Jia Y.   +21 more
europepmc   +4 more sources

All-in-One Digital Microfluidics System for Molecular Diagnosis with Loop-Mediated Isothermal Amplification [PDF]

Biosensors, 2022
In this study, an “all-in-one” digital microfluidics (DMF) system was developed for automatic and rapid molecular diagnosis and integrated with magnetic bead-based nucleic acid extraction, loop-mediated isothermal amplification (LAMP), and real-time ...
Siyi Hu, Yuhan Jie, Kai Jin, Yifan Zhang, Tianjie Guo, Qi Huang, Qian Mei, Fuqiang Ma, Hanbin Ma   +8 more
doaj   +3 more sources

Fabrication of Transparent and Flexible Digital Microfluidics Devices [PDF]

Micromachines, 2022
This study proposed a fabrication method for thin, film-based, transparent, and flexible digital microfluidic devices. A series of characterizations were also conducted with the fabricated digital microfluidic devices.
Jianchen Cai, Jiaxi Jiang, Jinyun Jiang, Yin Tao, Xiang Gao, Meiya Ding, Yiqiang Fan   +6 more
doaj   +3 more sources

Digital Microfluidics for Single Bacteria Capture and Selective Retrieval Using Optical Tweezers [PDF]

Micromachines, 2020
When screening microbial populations or consortia for interesting cells, their selective retrieval for further study can be of great interest. To this end, traditional fluorescence activated cell sorting (FACS) and optical tweezers (OT) enabled methods ...
Phalguni Tewari Kumar, Deborah Decrop, Saba Safdar, Ioannis Passaris, Tadej Kokalj, Robert Puers, Abram Aertsen, Dragana Spasic, Jeroen Lammertyn   +8 more
doaj   +3 more sources

Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq). [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Single-cell copy number variations (CNVs) reflect genetic variation and evolutionary. The accuracy of copy number variations counting relies on the fidelity of single-cell genome amplification.
Yu X, Ruan W, Lin F, Qian W, Zou Y, Liu Y, Su R, Niu Q, Ruan Q, Lin W, Zhu Z, Zhang H, Yang C.   +12 more
europepmc   +2 more sources

Conquering the Tyranny of Number With Digital Microfluidics [PDF]

Frontiers in Chemistry, 2021
The development of large-scale integration based on soft lithography has ushered a new revolution in microfluidics. This technology, however, relies inherently on pneumatic control of micromechanical valves that require air pressure to operate, while ...
Ya-Tang Yang, Tsung-Yi Ho
doaj   +2 more sources

An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system. [PDF]

Sci China Chem, 2022
Outbreaks of both influenza virus and the novel coronavirus SARS-CoV-2 are serious threats to human health and life. It is very important to establish a rapid, accurate test with large-scale detection potential to prevent the further spread of the ...
Sun Z, Lin KF, Zhao ZH, Wang Y, Hong XX, Guo JG, Ruan QY, Lu LY, Li X, Zhang R, Yang CY, Li BA.   +11 more
europepmc   +2 more sources

Deep Learning-Assisted Label-Free Parallel Cell Sorting with Digital Microfluidics. [PDF]

Adv Sci (Weinh)
Sorting specific cells from heterogeneous samples is important for research and clinical applications. In this work, a novel label‐free cell sorting method is presented that integrates deep learning image recognition with microfluidic manipulation to ...
Guo Z, Li F, Li H, Zhao M, Liu H, Wang H, Hu H, Fu R, Lu Y, Hu S, Xie H, Ma H, Zhang S.   +12 more
europepmc   +2 more sources

Characterization of Inkjet-Printed Digital Microfluidics Devices [PDF]

Sensors, 2021
Digital microfluidics (DMF) devices enable precise manipulation of small liquid volumes in point-of-care testing. A printed circuit board (PCB) substrate is commonly utilized to build DMF devices.
Shiyu Chen, Zhidong He, Suhwan Choi, Igor V. Novosselov   +3 more
doaj   +2 more sources

Machine vision-based driving and feedback scheme for digital microfluidics system

Open Chemistry, 2021
A digital microfluidic system based on electrowetting-on-dielectric is a new technology for controlling microliter-sized droplets on a plane. By applying a voltage signal to an electrode, the droplets can be controlled to move, merge, and split.
Luo Zhijie, Huang Bangrui, Xu Jiazhi, Wang Lu, Huang Zitao, Cao Liang, Liu Shuangyin   +6 more
doaj   +2 more sources