Results 51 to 60 of about 14,250 (247)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Persistence Statements: Describing Digital Stickiness

Data Science Journal, 2017
In this paper we present a draft vocabulary for making “persistence statements.” These are simple tools for pragmatically addressing the concern that anyone feels upon experiencing a broken web link.
John Kunze, Scout Calvert, Jeremy D. DeBarry, Matthew Hanlon, Greg Janée, Sandra Sweat   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Carta Editorial

Fronteiras: Journal of Social, Technological and Environmental Science, 2016
A primeira edição de 2016 da revista Fronteiras: Journal of Social, Technological and Environmental Science, está no ar com a notícia que a partir desse volume todos os artigos contarão com os registros no DOI (Digital Object Identifier).
Pedro Vitor Lemos Cravo, Sandro Dutra e Silva   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design and Implementation of Iranian Digital Object Recognizer (DOR) Phase 1: Persian Articles

International Journal of Information Science and Management, 2017
The Digital Object Recognizer (DOR) is a system for identifying Persian digital objects on the web. DOR is a unique alphanumeric string assigned by Regional Information Center for Science and Technology (RICeST) to any entity to identify content and ...
Mohammad Reza Ghane, Sara Koleini, Mohammad Bagher Dastgheib   +2 more
doaj  

S-ID: Implementing Intelligent Interoperability for Heterogeneous IoT Identifiers Through a Semantic-Based Framework

IEEE Access
In the Internet of Things (IoT), each object (i.e., an IoT instance) requires a unique identifier to serve as its digital fingerprint, enabling users to access detailed information about the object.
Shujuan You, Xiaotao Li, Hang Yu, Wai Chen   +3 more
doaj   +1 more source

Editorial

Revista de la Facultad de Derecho, 2016
El Consejo Editorial de la Revista de la Facultad de Derecho en su 41a edición, presenta este número dando a conocer a sus lectores y colaboradores en su carácter de autores o evaluadores, algunos logros relevantes alcanzados recientemente.
Comité Editor
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source