Results 41 to 50 of about 293,837 (250)

The ethical challenges of artificial intelligence‐driven digital pathology

The Journal of Pathology: Clinical Research, 2022
Digital pathology – the digitalisation of clinical histopathology services through the scanning and storage of pathology slides – has opened up new possibilities for health care in recent years, particularly in the opportunities it brings for artificial ...
Francis McKay, Bethany J Williams, Graham Prestwich, Daljeet Bansal, Nina Hallowell, Darren Treanor   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Understanding the financial aspects of digital pathology: A dynamic customizable return on investment calculator for informed decision-making

Journal of Pathology Informatics
Background: The adoption of digital pathology has transformed the field of pathology, however, the economic impact and cost analysis of implementing digital pathology solutions remain a critical consideration for institutions to justify.
Orly Ardon, Sylvia L. Asa, Mark C. Lloyd, Giovanni Lujan, Anil Parwani, Juan C. Santa-Rosario, Bryan Van Meter, Jennifer Samboy, Danielle Pirain, Scott Blakely, Matthew G. Hanna   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments

Transplant International, 2023
The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models for image analysis; and foster collaborations using regular videoconferencing.
Alton B. Farris, Mariam P. Alexander, Ulysses G. J. Balis, Laura Barisoni, Peter Boor, Peter Boor, Roman D. Bülow, Lynn D. Cornell, Anthony J. Demetris, Evan Farkash, Meyke Hermsen, Julien Hogan, Julien Hogan, Renate Kain, Jesper Kers, Jesper Kers, Jun Kong, Jun Kong, Richard M. Levenson, Alexandre Loupy, Maarten Naesens, Pinaki Sarder, John E. Tomaszewski, Jeroen van der Laak, Jeroen van der Laak, Dominique van Midden, Yukako Yagi, Kim Solez   +27 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

From Microscopes to Monitors: Unique Opportunities and Challenges in Digital Pathology Implementation in Remote Canadian Regions

Diagnostics
Background/Objectives: Digital pathology has the potential to revolutionize pathology diagnostics, especially in geo-graphically isolated and underserved regions.
Miquela Daniel, Klaudia Nowak, Rajkumar Vajpeyi, Blaise Clarke, Andrew Evans, Charlotte Carment-Baker, Karen Weiser, Mary Martin, Nancy Girard, Kate Fyfe, Shaza Zeidan, Christine Bruce, George M. Yousef   +12 more
doaj   +1 more source

The Role and Financial Implications of Digital Pathology for the System Health [PDF]

Ovidius University Annals: Economic Sciences Series, 2020
Public health system is under great pressure to cope with old and new threats which can have different causes. Progresses regarding methods of diagnosis and treatment options pushed the pathology filed to move forward.
Gabriela Izabela Băltățescu, Nicolae Dobrin, Ionut Burlacu   +2 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Expanding application of digital pathology in Japan - from education, telepathology to autodiagnosis

Diagnostic Pathology, 2011
Background Digital pathology, i.e., applications of digital information technologies to pathology practice, has been expanding in the recent decades and the mode of pathology diagnostic practice is changing with enhanced precision.
Tsuchihashi Yasunari
doaj   +1 more source