Results 31 to 40 of about 399,318 (247)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Enhancing Predictive Models to Lower Rehospitalization Risk: Utilizing Historical Medical Records for AI-Driven Interventions

IEEE Access
Artificial Intelligence (AI) models can predict patient readmission probabilities, aiding discharge decisions and preventing early discharges, which can lead to rehospitalization and related increased costs.
Giada Confortola, Mika Takata, Naoaki Yokoi, Masashi Egi   +3 more
doaj   +1 more source

AI-Driven Digital Platform Innovation

Technology Innovation Management Review, 2020
Artificial Intelligence (AI) innovation becomes useful today when it enriches decision-making that is enhanced by applications of big data (BD), advanced analytics (AA), and some element of human interaction using digital platforms. This research aims to
Sergey A. Yablonsky
doaj   +1 more source

Gaining consensus on expert rule statements for acute respiratory failure digital twin patient model in intensive care unit using a Delphi method

Biomolecules & Biomedicine, 2023
Digital twin technology is a virtual depiction of a physical product and has been utilized in many fields. Digital twin patient model in healthcare is a virtual patient that provides opportunities to test the outcomes of various interventions virtually ...
Amy J. Montgomery, John Litell, Johnny Dang, Laure Flurin, Ognjen Gajic, Amos Lal, on behalf of Digital Twin Platform for education, research, and healthcare delivery investigator group   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Parkinson’s disease severity clustering based on gait activity from mobile device

Scientific Reports
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including gait impairments, which significantly affect patient mobility and quality of life.
Panyawut Sri-iesaranusorn, Warisara Asawaponwiput, Pongsakorn Ajchariyasakchai, Roongroj Bhidayasiri, Decho Surangsrirat   +4 more
doaj   +1 more source

Research on value co-creation mechanism of platform enterprises in digital innovation ecosystem: A case study on Haier HOPE platform in China

Frontiers in Psychology, 2022
Digital technology has given the innovation subject a new way of value creation, expanded the existing innovation ecosystem theory, and triggered scholars’ in-depth thinking on the digital innovation ecosystem. Based on the event system theory and taking
Yuhua Li, Kaiwen Fu, Xiheng Gong, Ziwei Xiang, Jingyi Zhang, Chengjun Liao   +5 more
doaj   +1 more source

Digital Industrial Platforms [PDF]

Business & Information Systems Engineering, 2021
Tobias Pauli, Erwin Fielt, Martin Matzner   +2 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source