Results 51 to 60 of about 399,318 (247)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

What is beautiful is not always good: influence of machine learning-derived photo attractiveness on intention to initiate social interactions in mobile dating applications

Connection Science, 2021
The popularity of mobile dating applications has reconstructed how people initiate new romantic relationships. Photo attractiveness, the most prominent information provided in the online dating context before social interactions, has attracted ...
Ping Gao, Xiaolun Wang, Hong Chen, Weihui Dai, Hong Ling   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatialization of Digital Platforms

Social Media + Society
This article challenges the common tendency to pinpoint a “nationality” to a multi-national capitalist platform company. It calls for a close examination of how platform companies, as capitalist enterprises, organize themselves legally and spatially. The article first reviews how platforms have been studied in relation to space. I then use the case of
openaire   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Conducting marine genetic research for whom? Mapping knowledge flows from science to patents

npj Ocean Sustainability
Marine genetic resources hold great value for biotechnological innovation and sustainability-oriented research. However, studies indicate that intellectual property rights pertaining to these resources are concentrated in a handful of companies and ...
Paul Dunshirn, Erik Zhivkoplias
doaj   +1 more source

Attention-Driven Alaryngeal Speech Enhancement via Discrete Representation Learning and Timbre-Preserving Augmentation

IEEE Open Journal of the Computer Society
Alaryngeal speech enhancement seeks to restore intelligibility and naturalness for individuals who have undergone laryngectomy. Existing methods based on direct spectral mapping or frame-level voice conversion fail to exploit speech's linguistic ...
Hnin Yadana Lwin, Wuttipong Kumwilaisak, Chatchawarn Hansakunbuntheung, Nattanun Thatphithakkul   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Deep Learning Approaches for Classifying Crack States With Overload and Predicting Fatigue Parameters in a Titanium Alloy

Advanced Intelligent Systems
Crack retardation, commonly observed in metals under overload, helps extend fatigue life. Conventional methods for modeling behavior under variable loading are labor‐intensive and sensitive to measurement errors because they rely on cycle‐by‐cycle crack ...
Seon Du Choi, Suman Timilsina, Youn Woo Shin, Yong Nam Kwon, Kee‐Sun Sohn, Ji Sik Kim   +5 more
doaj   +1 more source

Designing for Comfort in VR Public Speaking: How Avatar Realism and Natural Environments Shape User Experience and Stress Responses

Behavioral Sciences
Virtual reality (VR) is increasingly used in public speaking training, yet the distinct roles of environmental context and virtual audience design remain unclear. This study examines how avatar visual style (realistic vs.
Han Zhang, Rui Peng, Shiyi Wang, Hanting Song, Zijian Li   +4 more
doaj   +1 more source