Results 61 to 70 of about 1,233,556 (275)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Digital Mapping of Soil Profile Properties for Precision Agriculture in Developing Countries

open access: yesAgronomy, 2022
The soil profile and its spatial distribution are two essential aspects for promoting sustainable agriculture, with precise inputs in quantity, space, and time.
Antonio López-Castañeda   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Exploring the Innovation Path of the Digital Construction Industry Using Mixed Methods

open access: yesBuildings, 2022
To provide a theoretical basis for deepening digital reform in the construction industry and explore the innovation path of the digital construction industry, this research uses patent data for Guangdong Province to carry out explanatory sequence ...
Xiaolong Xue   +4 more
doaj   +1 more source

AER Neuro-Inspired interface to Anthropomorphic Robotic Hand [PDF]

open access: yes, 2006
Address-Event-Representation (AER) is a communication protocol for transferring asynchronous events between VLSI chips, originally developed for neuro-inspired processing systems (for example, image processing).
Jiménez Moreno, Gabriel   +5 more
core  

Two-dimensional string notation for representing video sequences

open access: yes, 1995
Most current work on video indexing concentrates on queries which operate over high level semantic information which must be entirely composed and entered manually.
Kieronska, Dorota   +2 more
core   +1 more source

Temporal video transcoding from H.264/AVC-to-SVC for digital TV broadcasting [PDF]

open access: yes, 2015
Mobile digital TV environments demand flexible video compression like scalable video coding (SVC) because of varying bandwidths and devices. Since existing infrastructures highly rely on H.264/AVC video compression, network providers could adapt the ...
Cuenca, P   +5 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Vibration-Based Damage Detection in Wind Turbine Blades using Phase-Based Motion Estimation and Motion Magnification

open access: yes, 2018
Vibration-based Structural Health Monitoring (SHM) techniques are among the most common approaches for structural damage identification. The presence of damage in structures may be identified by monitoring the changes in dynamic behavior subject to ...
Mao, Zhu   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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