Results 101 to 110 of about 1,521,825 (346)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Reprogramming the hand: bridging the craft skills gap in 3D/digital fashion knitwear design [PDF]

open access: yes, 2013
Designer-makers have integrated a wide range of digital media and tools into their practices, many taking ownership of a specific technology or application and learning how to use it for themselves, often drawing on their experiential knowledge of ...
Taylor, J, Townsend, K
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

Digital skills and digital citizenship education: An analysis based on structural equation modeling

open access: yesJournal of Technology and Science Education
The main objective of this study is to examine the correlation between digital skills and their correlation with digital citizenship among students enrolled at a university in Peru.
Olger Gutiérrez-Aguilar   +6 more
doaj   +1 more source

“What do I need?” – evaluating learner perceptions of digital literacy skills development to inform enhancements to learning design

open access: yes, 2012
The ability to demonstrate digital literacy skills, defined by the European Commission as the confident and critical use of ICT for work, leisure, learning and communication, is a key requirement for graduates, demanded both by the UK Quality Assurance ...
Baker, Kirsty, Hall, Marion, Nix, Ingrid
core  

Community-based mentoring and innovating through Web 2.0 [PDF]

open access: yes, 2009
The rise of social software, often termed Web 2.0, has resulted in heightened awareness of the opportunities for creative and innovative approaches to learning that are afforded by network technologies.
Costa, Cristina, Keegan, Helen
core  

Technology, Pedagogy and Digital Production: A Case Study of Children Learning New Media Skills [PDF]

open access: yes, 2007
This article presents an analysis of data from a project which investigated children and young people's learning of digital cultures in informal settings in Britain. The project aimed to build links between young peoples' leisure and learning experiences,
Willett, Rebekah
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

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