Results 71 to 80 of about 1,521,825 (346)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Fostering Transdisciplinary Digital Institutional Leadership in Higher Education During Wartime [PDF]
Journal of Systemics, Cybernetics and InformaticsIn times of war and crisis, higher education institutions (HEIs) face unprecedented challenges requiring transdisciplinary adaptability, resilience, and innovative leadership.
Rusudan Makhachashvili +3 more
doaj
Developing a Framework for Evaluating the Skills and Morals of Digital Humanities Scholars [PDF]
International Journal of Ethics and Society, 2023 Introduction: Humanities studies aspects related to human civilizational, social and cultural characteristics. The present study was conducted with the aim of developing a framework for evaluating the skills of digital humanities scholars.
Faezeh Mesrinejad, Fatima Fahim Nia
doaj
Library Resources: Procurement, Innovation and Exploitation in a Digital World [PDF]
, 2011 The possibilities of the digital future require new models for procurement, innovation and exploitation. Emma Crowley and Chris Spencer describe the skills staff need to deliver resources in hybrid and digital environments.
Crowley, Emma J., Spencer, Chris
core
Digital curation skills in the performing arts: an investigation of practitioner awareness and knowledge of digital object management and preservation [PDF]
, 2014 This study examines the digital curation awareness and practice of a sample of practitioners from the UK performing arts community. Twelve performance arts practitioners from across the United Kingdom were interviewed to establish understanding of ...
Molloy, Laura
core +1 more source
How Digital Natives Learn and Thrive in the Digital Age: Evidence from an Emerging Economy [PDF]
, 2020 As a generation of ‘digital natives,’ secondary students who were born from 2002 to 2010 have various approaches to acquiring digital knowledge. Digital literacy and resilience are crucial for them to navigate the digital world as much as the real world;
Ho, Manh-Toan +11 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2014 The power relationship between adults and children in the West is shifting. Factors of age and life experience are becoming counterbalanced by children’s affinity for burgeoning developments in digital technology, where skills developed in online ...
Williams, Peter.
core +3 more sources
Next Generation User Skills [PDF]
, 2009 The world is awash with statistics on the impact of the web on 21st century living, learning and working. They are accompanied by the pronouncements and predictions of experts from every camp, from those heralding a new brave new world of co-creation and
Kay, David +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source