Results 51 to 60 of about 2,184,166 (294)
Bidirectional reinforcement learning neural network for constrained molecular design
Scientific ReportsWe present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin +5 more
doaj +1 more source
Systematic literature review of digital and green transformation of manufacturing SMEs in Europe
Production and Manufacturing Research: An Open Access JournalThe digital and green transformation of the manufacturing industry is gaining attention in research and practice, often referred to as twin transition. However, understanding twin transitions in SMEs is limited.
Anar Abilakimova +2 more
doaj +1 more source
Threat Modelling and Beyond-Novel Approaches to Cyber Secure the Smart Energy System
Applied Sciences, 2021 Smart Grids (SGs) represent electrical power systems that incorporate increased information processing and efficient technological solutions. The integration of local prosumers, demand response systems and storage allows novel possibilities with regard ...
Heribert Vallant +3 more
doaj +1 more source
Rethinking young children creating and communicating : research briefing 3 for digital childhoods [PDF]
, 2011 This briefing paper specifically considers children’s early communicative and creative experiences with digital technologies, addressing the following questions: »» What are children learning about the roles digital technologies play in supporting ...
Mcpake, Joanna
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
VNFlow: integration of variational autoencoders and normalizing flows for novel molecular design
Journal of CheminformaticsGenerative Artificial Intelligence is transforming the molecular discovery by enabling exploration of the vast, largely unexplored chemical space. However, current methods, including normalizing flows, struggle to balance the optimization of complex ...
Jiří Hostaš +5 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Processing mathematics through digital technologies: A reorganisation of student thinking? [PDF]
, 2011 This article reports on aspects of an ongoing study examining the use of digital media in mathematics education. In particular, it is concerned with how understanding evolves when mathematical tasks are engaged through digital pedagogical media in ...
Calder, Nigel Stuart
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Constructing digital library interfaces [PDF]
, 2007 The software technologies used to create web interfaces for digital libraries are discussed using examples from Greenstone ...
Bainbridge, David +2 more
core +2 more sources