Results 21 to 30 of about 907,009 (257)

Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach

open access: yesScientific Reports, 2021
Drug repurposing is one of the modern techniques used in the drug discovery to find out the new targets for existing drugs. Insilico methods have a major role in this approach.
D. R. Sherin, T. K. Manojkumar
doaj   +1 more source

Investigation of Resonance Avoidance Method for Vacuum Cleaner

open access: yesIEEE Open Journal of Industry Applications, 2023
Electromagnetic resonance in electric motors arises when the electromagnetic force frequency coincides with any of the motor's natural frequencies, causing excessive vibration and noise.
Woong Hwang   +4 more
doaj   +1 more source

Online battery health diagnosis for electric vehicles based on DTW-XGBoost

open access: yesEnergy Reports, 2022
With the rapid development of electric vehicles, electric vehicle battery health diagnosis has become a hot issue. In order to realize online battery health diagnosis, an online battery health diagnosis platform based on DTW-XGBoost was proposed.
Na Yan   +9 more
doaj   +1 more source

Digitalization Technologies for Industrial Sustainability

open access: yesProcedia Manufacturing, 2019
Abstract Digital technologies are shown to perform a potential role in developing a resource efficient industrial base. The effective adoption of them can help to deliver reduced costs and improve the flexibility and sustainability of manufacturing systems.
Demartini M., Evans S., Tonelli F.
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Improved Structural Analysis Method for Isolator with Quasi-Zero-Stiffness Characteristic

open access: yesShock and Vibration, 2021
A typical quasi-zero-stiffness (QZS) vibration isolator consisting of a vertical spring and two oblique springs has been widely researched on its static and dynamic characteristics.
Wei Zhang   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Unleashing Green Innovation in Enterprises: The Transformative Power of Digital Technology Application, Green Human Resource, and Digital Innovation Networks

open access: yesSystems, 2023
The rapid development of digital technology has injected new vitality into green technological innovation within manufacturing enterprises. Proper application of digital technology during the innovation process can propel global sustainable development ...
Jian Liu, Qibin Wang, Chaoyi Wei
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Deep learning-based identification of patients at increased risk of cancer using routine laboratory markers

open access: yesScientific Reports
Early screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to determine the ...
Vivek Singh   +8 more
doaj   +1 more source

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