Results 31 to 40 of about 43,125,470 (302)

Digital Library Access For Illiterate Users [PDF]

, 2004
The problems that illiteracy poses in accessing information are gaining attention from the research community. Issues currently being explored include developing an understanding of the barriers to information acquisition experienced by different groups ...
D. M. Nichols, S. Deo, I. H. Witten, Nichols, David M., S. J. Cunningham, M. F. Trujillo, Cunningham, Sally Jo, Witten, Ian H., Deo, Shaleen, Trujillo, Maria F.   +9 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An Improved Structural Analysis Method for Isolator with Quasi-Zero-Stiffness Characteristic

Shock and Vibration, 2021
A typical quasi-zero-stiffness (QZS) vibration isolator consisting of a vertical spring and two oblique springs has been widely researched on its static and dynamic characteristics.
Wei Zhang, Xiaoping Li, Jian Li, Xiqiu Li   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Prediction uncertainty estimates elucidate the limitation of current NSCLC subtype classification in representing mutational heterogeneity

Scientific Reports
The heterogeneous pathogenesis and treatment response of non-small cell lung cancer (NSCLC) has led clinical treatment decisions to be guided by NSCLC subtypes, with lung adenocarcinoma and lung squamous cell carcinoma being the most common subtypes ...
Andrei Puiu, Carlos Gómez Tapia, Maximilian E. R. Weiss, Vivek Singh, Ali Kamen, Matthias Siebert   +5 more
doaj   +1 more source

Research on the Design of Proton Therapy Monitoring System Based on Domestic SCADA Platform

Zhongguo yiliao qixie zazhi
Proton therapy monitoring system is an important component of proton therapy system. In view of the high-precision and high-reliability requirements of proton therapy equipment for the monitoring system, this paper presents a design scheme of proton ...
Yifan LIU, Feiyang HAN, Zhiwu GUO, Da HUANG, Hongliang ZHANG   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Unleashing Green Innovation in Enterprises: The Transformative Power of Digital Technology Application, Green Human Resource, and Digital Innovation Networks

Systems, 2023
The rapid development of digital technology has injected new vitality into green technological innovation within manufacturing enterprises. Proper application of digital technology during the innovation process can propel global sustainable development ...
Jian Liu, Qibin Wang, Chaoyi Wei
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Hybrid neural network for personnel recognition and tracking in remote bidding evaluation monitoring

Scientific Reports
Unauthorized access to the bidding evaluation office and the departure of experts can significantly compromise the quality of on-site assessment work and introduce substantial integrity risks.
Zhihao Zhou, Zhan Wang, Yuwei Meng, Rongdong Yu, Xingwei He, Ding Lu, Wei Wang   +6 more
doaj   +1 more source