Results 51 to 60 of about 1,680,483 (305)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Humanization of digital technologies

Human Technology
This editorial introduces the special issue arising from the "11th International Conference on Communities and Technologies - Humanisation of Digital Technologies". It sets the stage for a series of papers that illustrate a shift from technology-centred to human-centred approaches in the development of digital technologies. The editorial highlights the
Siemon Dominik, Wolff Annika
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

DIGITAL TECHNOLOGY IN PHOTOGRAMMETRY

Journal of Engineering, 2005
One of the major advantages of digital photogrammetry is the potential to automate production processes efficiently, thus substantially improving the price performance ratio for photogramnetric products.
Fanar Mansour
doaj   +1 more source

Idecomp: imbalance-aware decomposition for class-decomposed classification using conditional GANs

Discover Artificial Intelligence, 2023
Medical image classification tasks frequently encounter challenges associated with class imbalance, resulting in biased model training and suboptimal classification performance.
Patryk Buczek, Usama Zidan, Mohamed Medhat Gaber, Mohammed M. Abdelsamea   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Digital stethoscope: technology update

Medical Devices: Evidence and Research, 2018
Supreeya Swarup,1 Amgad N Makaryus1,2 1Department of Cardiology, Nassau University Medical Center, East Meadow, NY, 2Department of Cardiology, Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY, USA Abstract: Cardiovascular disease (CVD)
Swarup S, Makaryus AN
doaj  

A Modular Heuristic-Based Solution for Large-Scale Outage Management in Nuclear Power Plants [PDF]

EPJ Web of Conferences
The Resource Constrained Project Scheduling Problem (RCPSP) is a prominent combinatorial optimization problem in academia. It involves scheduling project activities while considering constraints arising from logical relationships between tasks, resource ...
Ninpan Khwansiri, Huang Shuzhang, Moro Maxime, Malhomme Olivier, Aumont Arthur, Assaad Mohamad Ali, Vitillo Francesco, Bureau Nicolas, Bechet Lies Benmiloud, Plana Robert   +9 more
doaj   +1 more source

Exploring factors influencing pre-service teacher’s digital teaching competence and the mediating effects of data literacy: empirical evidence from China

Humanities & Social Sciences Communications, 2023
The development of pre-service teachers’ digital teaching competence is crucial for effectively infusing technology into teaching. With the growing importance of data in education, it is imperative to explore the influencing factors of digital teaching ...
Juan Chu, Ruyi Lin, Zihan Qin, Ruining Chen, Ligao Lou, Junfeng Yang   +5 more
doaj   +1 more source